Study of nonrandom chromosome aberrations in bone marrow and blood cells of patients with non-Hodgkin's lymphomas.

Complete karyotyping of G-stained chromosomes of bone marrow and blood cells was carried out in patients with non-Hodgkin's lymphomas before and after antitumor therapy, in remissions and relapses. Clones with 1q41-43, 2q35, and 6q24-27 deletions were most incident. Their incidence in patients increased after antitumor therapy.

Cytogenetic study of bone marrow and blood cells in patients with non-Hodgkin lymphoma before and after antitumor therapy.

Non-clonal and clonal abnormal cells (hypodiploid, polyploid, and with chromosome aberrations) were detected by the G-method in the bone marrow and blood of the majority of patients with non-Hodgkin lymphomas before therapy. The manifestation of these abnormalities changed individually after treatment. The most incident were clones -22, del(1)(q42-43), del(2)(q-33-35), del(3)(q27), 4q-, and del(6q).

[Analysis of stable chromosome aberrations using G-banding stain in lymphocyte of patients with high dose radiation injury].

The analysis was performed on 514 blood lymphocytes from a person accidentally exposed to 137Cs. Blood samples were collected 1 year after exposure three times at intervals of one month. Terminal deletions and simple translocations were found to predominate in all cases.

[A comparative study of the frequency of stable and unstable chromosome aberrations in the gamma irradiation of human lymphocytes in vitro].

Comparative studies of the yield of stable and unstable chromosome aberrations have been carried out in human lymphocytes gamma irradiated in vitro within the doze range 0.1--1.0 Gy.