Publications by authors named "M A Ajani"
Introduction: cervical cancer is primarily driven by high-risk human papillomavirus infections. It is a leading cause of cancer-related deaths among women globally. The emergence of immunotherapeutic approaches, particularly programmed death ligand-1 (PD-L1) inhibitors, has shown promise in various cancers.
View Article and Find Full Text PDFBackground And Objective: The demonstration of HER2 in gastric adenocarcinoma (GA) tissues by immunohistochemistry assists in deciding whether targeted therapy would optimise the treatment of GA patients who are HER2 positive. However, this has not been extensively studied in our patients hence the need for this study.
Methods: Recipient tissue microarray blocks were constructed from donor archival formalin fixed paraffin embedded gastric tumour tissue from 80 patients seen over a period of 17 years in a retrospective descriptive study.
Article Synopsis
- Black women have the highest breast cancer mortality rates, prompting a study on the VEGF-hypoxia gene expression signature across diverse populations, specifically focusing on breast tumors from Nigeria and Chicago.
- A new gene expression panel was used to find that the VEGF-hypoxia signature is most prevalent in the basal-like subtype of breast cancer, particularly in Black women, and is associated with necrotic tumors showing links to proliferation.
- The study highlights the need for targeted interventions addressing the VEGF-hypoxia signature and the immune microenvironment to improve survival rates in aggressive breast cancers affecting Black women.
Background: Ovarian cancer is the leading cause of death from all gynaecological malignancies. Only few biomarkers of epithelial ovarian cancer (EOC) prognosis have been studied so far among Nigerian patients.
Objective: To determine the pattern of oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) expression in patients with EOC seen in Nigeria.
Introduction: Most cases of Meckel's Diverticulum (MD) are asymptomatic and when symptomatic, preoperative diagnosis of MD maybe a dilemma. Intestinal obstruction is a major complication in the adult population.
Case Presentation: We report a case of a 24-year-old female presenting with intestinal obstruction from Meckels Diverticulum.