Capsaicin/silica-infused polygalacturonic acid/polyvinyl alcohol nano-matrix for enhanced wound healing in skin injuries.

Wound healing is a complex physiological process, demanding advanced strategies for efficient tissue regeneration. To address this, we developed a novel nanofibrous matrix composed of polygalacturonic acid (PGA), polyvinyl alcohol (PVA), capsaicin, and zinc-doped mesoporous silica (Zn/MCM-41). This copolymeric matrix offers enhanced mechanical stability, controlled drug release, and improved cellular adhesion and proliferation, leading to effective tissue regeneration.

Insights into particle dispersion and damage mechanisms in functionally graded metal matrix composites with random microstructure-based finite element model.

This study investigates the impact of particle volume fraction and distribution on the deformation and damage of particle-reinforced metal matrix composites, particularly in the context of functionally graded metal matrix composites. In this study, a two-dimensional nonlinear random microstructure-based finite element modeling approach implemented in ABAQUS/Explicit with a Python-generated script to analyze the deformation and damage mechanisms in composites. The plastic deformation and ductile cracking of the matrix are captured using the Gurson-Tvergaard-Needleman model, whereas particle fracture is modelled using the Johnson-Holmquist II model.

Controlling wind turbine tower vibration under external force by applying control systems combination.

The global focus has recently shifted away from fuel-based power sources, and one of the most important projects for energy production is wind energy. To maintain low costs, the current research examines the problem of vibrations affecting wind turbine towers' performance (WTTs). In particular, the tower, resulting from excessive vibrations, can negatively affect a structure's power output and service life, as it can cause fatigue.

Advances in active targeting of ligand-directed polymeric nanomicelles exploiting overexpressed cellular receptors for precise nanomedicine.

Many of the utilized drugs which already exist in the pharmaceutical sector are hydrophobic in nature. These drugs are characterized by being poorly absorbed and difficult to formulate in aqueous environments with low bioavailability, which could result in consuming high and frequent doses in order to fulfil the required therapeutic effect. As a result, there is a decisive demand to find modern alternatives to overcome all these drawbacks.