Publications by authors named "M A Adlan"
Universal salt iodisation (USI) plays an essential role in the provision of iodine (I) to populations worldwide. Countries adopting USI programmes, adhering to strict criteria laid down by expert organisations such as the Iodine Global Network, are estimated to have reduced the prevalence of I deficiency by 75% (protecting 720 million individuals worldwide). Despite this success, doubts have been raised as to the desirability of continuing such programmes because of (a) the need to reduce salt intake for cardiovascular prevention and (b) the induction of thyroid autoimmunity.
View Article and Find Full Text PDFThrombopoietin (THPO) is a regulator of megakaryopoiesis and thrombopoiesis. Mutation of the gene is known to cause congenital amegakaryocytic thrombocytopenia (CAMT2), which is a rare inherited disorder characterized by early infancy thrombocytopenia and absent or decreased megakaryocytes with gradual progression to pancytopenia. We report the case of a Saudi girl who had been asymptomatic until age seven when she was found to have unexplained thrombocytopenia.
View Article and Find Full Text PDFDesigning a combined liothyronine (LT3), L- thyroxine (LT4) trial in symptomatic hypothyroid subjects on LT4 - the importance of patient selection, choice of LT3 and trial design.
Front Endocrinol (Lausanne)
December 2023
Article Synopsis
- - Around 10%-15% of hypothyroid patients taking L-thyroxine (LT4) still report ongoing symptoms that negatively impact their quality of life, potentially due to insufficient tissue levels of T3.
- - Although combining liothyronine (LT3) with LT4 seemed beneficial, randomized controlled trials did not show significant improvement over LT4 alone, which might be due to trial design flaws and inadequate measures.
- - Future studies should focus on better subject selection, utilize appropriate assessment tools for thyroid-related symptoms, employ long-acting LT3 formulations, and consider crossover designs to improve the reliability and efficiency of the trials.
Pre-test Cortisol Levels in Predicting Short Synacthen Test Outcome: A Retrospective Analysis.
Clin Med Insights Endocrinol Diabetes
May 2022
Objective: Short Synacthen tests (SSTs) are expensive, dependent on Synacthen availability, and need supervision. To reduce SST testing, we examined the utility of pre-test cortisol (Cort0) and related parameters in predicting outcome.
Design And Measurements: We retrospectively examined the following in all SSTs; (i) Cort0 (ii) indications (iii) and time and place of testing.
Myositis, rhabdomyolysis and severe hypercalcaemia in a body builder.
Endocrinol Diabetes Metab Case Rep
July 2020
Summary: A 53-year-old man who used growth hormone (GH), anabolic steroids and testosterone (T) for over 20 years presented with severe constipation and hypercalcaemia. He had benign prostatic hyperplasia and renal stones but no significant family history. Investigations showed - (1) corrected calcium (reference range) 3.
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