Hippuric acid, a uremic toxin, binds to aggregation prone region of human lysozyme and potentiates the fibrillation: a biophysical insight.

End-stage renal disease (ESRD) and human lysozyme (HL) amyloidosis are often interconnected, typically marked by elevated levels of uremic toxins in patients' blood. In this context, hippuric acid (HA), a uremic toxin derived from the metabolism of aromatic compounds, was investigated in vitro for its impact on HL fibrillation using spectroscopic, calorimetric, and computational methods. The results indicate that HA enhances HL fibrillation in a concentration-dependent manner, evidenced by increased ThT fluorescence and the detection of amyloid fibrils with a hydrodynamic radius of approximately 840.

Economic and technical analysis of hydrogen production and transport: a case study of Egypt.

This study investigates the economic, technical, and logistical aspects of hydrogen production, with a particular focus on Egypt's potential to emerge as a global hydrogen leader. The research is motivated by Egypt's abundant renewable resources, strategic location, and increasing interest in hydrogen as a cornerstone of the energy transition. Using the Hydra simulation model developed in MATLAB/Simulink, the study evaluates the Levelized Cost of Hydrogen (LCOH) and Levelized Supply Costs of Hydrogen (LSCOH) across various scenarios, spanning from 2024 to 2050.

Sildenafil Abrogates Radiation-induced Hepatotoxicity In Animal model: The impact of NF-κB-p65, P53, Nrf2, and SIRT 1 pathway.

Unlabelled: Ionizing radiation has both beneficial and harmful effects on human health, prompting researchers to find ways to protect organs from its adverse impacts. Sildenafil (SIL) has gained attention in protective medicine due to its antioxidant, anti-inflammatory, and anti-apoptotic properties.

Aim: This study aimed to investigate SIL's protective mechanisms against radiation-induced liver damage.

Bioactive chitosan based coating incorporated with essential oil to inactivate foodborne pathogen microorganisms and improve quality parameters of beef burger.

The aim of this study is to assess the impacts of chitosan (CH) coating with oregano essential oil (OEO) and thyme essential oil (TEO) (0.5%-1.0%; ) on the foodborne pathogens and physicochemical parameters of beef burger during refrigerated storage.

Prevalence and Association of Malaria With ABO Blood Groups in Bosaso City, Puntland, Somalia: A Cross-Sectional Study.

Background And Aims: Malaria remains a global health concern, with an estimated 249 million cases annually and 2.2 billion people at risk of infection. This study aimed to investigate the association between malaria species and ABO blood groups and identify the relationship between ABO blood groups and parasitemia.