Biomarkers.

Background: Identification of cognitively unimpaired (CU) individuals who may progress to mild cognitive impairment (MCI), is a pressing issue in the Alzheimer's disease (AD) field, since therapeutic interventions may be more effective in the absence of cognitive impairment and neurodegeneration. CU individuals positive for amyloid and tau PET are very likely in the AD pathway. In out-patient cognitive screening, we use rapid and simple tests such as The Montreal Cognitive Assessment (MoCA) - a composite of executive, visuospatial, naming, attention, language, abstraction, delayed recall, and orientation performances.

Alzheimer's Imaging Consortium.

Background: Identification of cognitively unimpaired (CU) individuals who may progress to mild cognitive impairment (MCI), is a pressing issue in the Alzheimer's disease (AD) field, since therapeutic interventions may be more effective in the absence of cognitive impairment and neurodegeneration. CU individuals positive for amyloid and tau PET are very likely in the AD pathway. In out-patient cognitive screening, we use rapid and simple tests such as The Montreal Cognitive Assessment (MoCA) - a composite of executive, visuospatial, naming, attention, language, abstraction, delayed recall, and orientation performances.

Glabridin Hypnosis in Zebrafish Larvae Is Associated With Effects on Multiple Anesthetic Target Receptors.

Background: R-Glabridin is a major flavonoid of licorice (Glycyrrhiza glabra) root and known to modulate GABAA receptors, which are targets of many clinical hypnotics. However, R-glabridin hypnotic activity has not been reported in animals.

Methods: Inverted photomotor responses (IPMRs) were used to assess the hypnotic effects of natural R-glabridin and synthetic R/S-glabridin in wild-type zebrafish larvae and transgenic larvae lacking functional GABAA receptor β3 subunits (β30/0).

Leishmania (Leishmania) amazonensis and Leishmania (Leishmania) infantum sialic acids enhance macrophage infection.

Leishmaniases affect millions of people around the world, caused by Leishmania parasites. Leishmania are transmitted by female sandflies from Phlebotominae subfamily during their blood meals. In mammals, promastigotes are phagocytosed mainly by macrophages, differentiate into amastigotes and multiply.

Educational technologies to promote the quality of life of people with diabetes: quasi-experimental study.

Objective: to verify the effect of educational technologies on the quality of life of people with diabetes.

Method: quasi-experimental study, before-and-after type, developed with a group of 34 people. Six interventions were carried out, in groups or individually, using educational technologies, such as clinical simulators and physical educational games.