Publications by authors named "M -R Losser"
Article Synopsis
- Intra-abdominal candidiasis (IAC) is challenging to diagnose in critically ill patients, often leading to excessive antifungal treatments; current markers like serum and peritoneal 1.3-beta-D-glucan (sBDG and pBDG) have shown inconsistent results in identifying IAC due to varying patient populations.
- This study investigated a high-risk population of critically ill patients undergoing abdominal surgery, aiming to determine the prevalence of IAC and the effectiveness of sBDG and pBDG in its diagnosis, finding a 44% prevalence rate among 199 included patients.
- Results showed that pBDG levels were significantly higher in patients with IAC compared to those without, suggesting pBDG could be
Reappraisal of intra-abdominal candidiasis: insights from peritoneal fluid analysis.
Intensive Care Med Exp
September 2023
Background: The understanding of high mortality associated with intra-abdominal candidiasis (IAC) remains limited. While Candida is considered a harmless colonizer in the digestive tract, its role as a true pathogen in IAC is still debated. Evidence regarding Candida virulence in the human peritoneal fluid are lacking.
View Article and Find Full Text PDFBackground: The immuno-receptor Triggering Expressed on Myeloid cells-1 (TREM-1) is activated during bacterial infectious diseases, where it amplifies the inflammatory response. Small studies suggest that TREM-1 could be involved in viral infections, including COVID-19. We here aim to decipher whether plasma concentration of the soluble form of TREM-1 (sTREM-1) could predict the outcome of hospitalized COVID-19 patients.
View Article and Find Full Text PDFObjective: To evaluate the value of hematocrit for monitoring fluid resuscitation of burn patients in the acute phase of their care.
Method: We conducted a single-center retrospective study focused on patients admitted with a burn surface of more than 20 % of the total body surface area (TBSA) from 2014 to 2021. We investigated the relationship between the change in hematocrit and the volume administered for patient resuscitation.
Background: Patients with obesity are at increased risk of severe COVID-19, requiring mechanical ventilation due to acute respiratory failure. However, conflicting data are obtained for intensive care unit (ICU) mortality.
Objective: To analyze the relationship between obesity and in-hospital mortality of ICU patients with COVID-19.