Publications by authors named "M'Hamdi H"
The Dutch Health Council has advised to extend the 14-day rule to 28 days and to subsume integrated stem cell-based embryo models under the same legislative regime as natural embryos. Public discussion is necessary due to the ethical issues that may emerge from studying integrated and non-integrated embryo models.
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- The legal definition and protection of human embryos vary significantly around the world, leading to differing interpretations and regulations.
- The use of human pluripotent stem cells to create in vitro models of early embryos has sparked debate about existing legal definitions and their implications.
- The authors propose a new legal definition of an embryo, identify key "tipping points" for recognizing embryo models, and recommend ethical principles for their responsible use to benefit society.
This study aimed to assess the welfare of Tunisian sheep in extensive sheep production systems using animal-based measures of ewe welfare. This study encompasses the first national survey of sheep welfare in which animal-based outcomes were tested. Animal-based welfare measures were derived from previous welfare protocols.
View Article and Find Full Text PDFObjective: in the promotion of periconceptional health, appropriate attention has to be given to the perceptions of those who are most vulnerable, such as women with a relatively low socioeconomic status based on their educational attainment. The aim of this study was to explore these women's perceptions of pregnancy preparation and the role they attribute to healthcare professionals.
Design: we conducted semi-structured interviews with women with a low to intermediate educational attainment and with a desire to conceive, of which a subgroup had experience with preconception care.
Article Synopsis
- Oral administration of antigens (Ag) triggers regulatory T cells that carry latent TGF-β, crucial for oral tolerance development.
- An in vitro study showed that specific antibodies and IL-2 can promote latent membrane-bound TGF-β expression on naive CD4 T cells without needing Foxp3 or external TGF-β.
- Pro-inflammatory cytokines like IL-6 hinder the induction of these regulatory T cells, suggesting that targeting the IL-6 pathway might improve oral tolerance and help manage autoimmune conditions.
Objectives To examine health care professionals' views of their role and responsibilities in providing preconception care and identify barriers that affect the delivery and uptake of preconception care. Methods Twenty health care professionals who provide preconception care on a regular basis were interviewed using semi-structured interviews. Results We interviewed twelve community midwives, three General Practitioners, three obstetricians, one cardiologist specialized in congenital heart diseases and one gastroenterologist.
View Article and Find Full Text PDFBackground: The role of IGF-1 in promoting cancer has been investigated for many years. The aim of this study is to explore the relationship between rates of IGF-1 and NPC and to evaluate association of IGF-1 with clinical parameters.
Materials And Methods: IGF-1 levels was measured by Elisa test among 82 NPC patients and 60 healthy controls
Results: Our results showed, for the first time, a significant increased levels of IGF-I in NPC by in comparison with healthy controls (p<0.
Article Synopsis
- γδ T cells are a specialized type of lymphocyte that help protect the body from infections and tumors.
- A specific subset of these cells, which express the latency-associated peptide (LAP), migrates to the intestines and alters their functioning, taking on a regulatory role.
- These TCRγδ+LAP+ cells can present antigens and promote the development of other regulatory T cells, offering insights into immune regulation and intestinal health.
Article Synopsis
- Fetal cells enter the maternal bloodstream during pregnancy, leading to a condition called microchimerism, where these cells persist for decades and may influence maternal health and tissue repair.
- Researchers tested the theory that the fetal microchimeric cells are primitive stem cells, specifically CD34+ adherent cells, found in the blood of pregnant women.
- The study found a significant presence of these fetal cells in the adherent CD34+ cell population and identified markers indicating their stem cell characteristics, suggesting they could sustain a long-term fetal presence in the mother's body.
Article Synopsis
- A Phase I study was conducted to evaluate the safety of injecting patients with liver insufficiency with their own CD34(+) stem cells, which were believed to have regenerative potential.
- The CD34(+) cells were separated into two groups based on their adherence to culture plastic, showing distinct characteristics that suggested some could differentiate into various tissue types, including liver cells.
- Following the injections, no serious complications occurred, and some patients showed improved liver function markers, indicating the need for further research.
Potter's reno-facial syndrome is a rare innate abnormality. We bring 4 observations repertoried at the maternity of military hospital of Tunis over a period of 6 years (1997 - 2002). The purpose of our work is to determine after a review of the literature the echographic and foetopathologic characteristics, and the forecast of this syndrome.
View Article and Find Full Text PDFWe compared the survival requirements of early- and late-born motoneurons from E5 chicken spinal cord. Density gradient centrifugation followed by immunopanning using SC1 antibody allowed us to purify two size classes of motoneuron. Large motoneurons retained by 6.
View Article and Find Full Text PDFMotoneurons were identified in vitro by a new method using the SC1 monoclonal antibody. They constituted up to 30% of total neurons in cultures of whole spinal cord from 4.5-day chicken embryos, and survived for at least 5 days in the presence of muscle extract, but not in its absence.
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