[The role of branched-chain amino acids metabolism in development of cardiovascular diseases and its risk factors].

Branched-chain amino acids play the key role in many metabolism processes in organism generally and in cardiovascular protection. It was discovered its importance in mitochondrial biogenesis, antioxidant and antiaging processes, its antihypertension and antiarrhythmic effects, its role in obesity and diabetes mellitus.

[Postprandial hypotension].

Postprandial hypotension is the independent risk factor of general mortality, coronary disorders and stroke. It is reviewed risk factors, pathogenesis, symptoms, treatment and prognosis of this disease.

[Age-related features of neurohumoral effects of dopamine activity on the cardiovascular system in elderly people].

Determined the decrease in dopamine activity with age, that contributes to the pathogenesis of hypertension, abdominal obesity, the development of left ventricular hypertrophy. The article presents information describing the age-sensitive regulation of the cardiovascular system in elderly people, confirming the influence of the activity of dopamine receptors in the development of age pathology.

[Changes of fatty acids spectrum of plasma triglycerides and their pharmacological correction by statins in patients with unstable angina].

The fatty acid composition of plasma triglycerides by gas chromatography, the dynamics of the segment ST, cardiac arrhythmia by daily monitoring of electrocardiogram in patients with unstable angina (progressive) and the effects of treatment with statins were studied. Revealed marked qualitative abnormalities of plasma triglycerides in patients with progressive angina manifest increase in the amount of saturated and reduction--of unsaturated fatty acids. High therapeutic effect of simvastatin and atorvastatin may be due to the identified strong correlation between the dynamics of the fatty acid components of plasma triglycerides and indicators of ischemia, ectopic activity in patients with progressive angina.

[Heart rhythm in humans with different processing levels of acoustic information].

The peculiarities of the heart rhythm regulation were investigated in humans during the processing of acoustic information. Statistically significant differences were found in individuals with different levels of auditory-motor reactions according to the heart rhythm characteristics. Individuals with the high level of reactions were characterized by significantly lower total power spectrum (TP=1276.

[Metabolism of polyunsaturated fatty acids and its value for a human body].

The article is devoted to the study of metabolism of polynonsaturated fat acids in a human body as antiatherogenous which prevents the development of cardiovascular diseases (ischemic heart disease, hypertension), as well as oncological diseases, a peptic ulcer of the stomach and duodenum.

[Immunoglobulins of blood serum in patients with stable and unstable angina].

Article is devoted to the study of immunoglobulins (Ig) classes A, G and M in blood serum of patients with stable and unstable clinical course of ischemic heart disease that improve our knowledge about immuneinflammatory process which develops under destabilization of a coronary circulation.

[Changes of fatty acid spectrum of thrombocyte lipids in patients with a stable and unstable angina].

Ischemic heart desease (IHD) remains actual issue of the current clinical medicine, because, IHD takes a leading position among reasons of death rate of population. Purpose of the study was to find diagnostic features of fat-acid composition of lipid of thrombocytes in patients with stable and unstable course of ischemic heart disease (IHD). 52 patients with an unstable angina pectoris aged 42-65 years and 31 patients with stable angina aged 41-66 years have been observed.

[Level of steroid hormones in patients with bronchial asthma combined with hypertension and their dynamics after using antihypertensive medications].

59 patients with bronchial asthma (BA) combined with hypertension have been observed. The authors have studied the level changes of cortisol and sexual hormones. Considerable decrease in level of progesterone and cortisol, and also increase in the level of estradiol have been revealed in the patient's blood.

[State of cellular and humoral immunity in patients with stable angina].

The article presents results of the analysis of indicators immunogenotypic tests of 104 patients with stable stenocardia I-III functional classes. It was established that patients with stable stenocardia have lower level of CD3+ T- lymphocytes, decreased rate of T- lymphocytes helpers/ suppressors (CD4+/CD8+) and increased concentration of circulating immune complexes. These changes did not depend from Functional class of stenocardia and old myocardial infarction.

[Phospholipids composition of the myocardium in patients with ischemic heart disease and its connection to arrhythmias].

The purpose of this study was to establish phospholipid composition of the myocardium in patients with ischemic heart disease, and to estimate possible correlation of biochemical parameters with myocardium extrasystolic activity. The patients (n = 28) including 15 patients with ischemic heart disease and 13 patients with secondary atrium septum defect (control group) were studied. During surgical intervention the right atrium myocardium bioptates were taken.

[Connection of endothelial dysfunction and level of blood leukocytes with clinical course of stable angina pectoris in patients with ischemic heart disease].

The authors presents in the article information on influence of endothelial dysfunction and level of blood leukocytes with clinical course of stable angina pectoris in patients with ischemic heart disease (IHD). 104 male patients aged from 36 to 69 (on average 54.9+/-2.

[Changes of electrocardiography parameters in patients with bronchial asthma and arterial hypertention].

The authors presents in the article based on observations of 89 patients questions related to the changes of intracardial hemodynamics in patients with bronchial asthma and arterial hypertention (AH) observed using echocardiography. Disorders of indices of intracardial hemodynamics in patients with bronchial asthma and arterial hypertention have more evident negative tendency than that in patients with isolated bronchial asthma (BA) or arterial hypertention. It was established that such patients (without taking into consideration the degree of severity of BA) have considerably an increased volume indices of left and right ventricule, increased pressure in the lung artery, right ventricule hypertrophy, left ventricule concentric hypertrophy as well as disorders of diastolic heart function of relaxation type.

[Early and late biomarkers of late myocardium necrosis in patients with acute coronary syndrome].

Cardio-vascular diseases and acute coronary syndrome (ACS) in the first place play the first role in the structure of diseases and mortality of world population. Effective method of diagnostics of ACS consists in detecting early and late biomarkers of myocardium necrosis. The article presents characteristics of such biomarkers indices as myoglobin, cardiotroponins, MB-fractions of creatine phosphokinase, cardio-form of protein, lactate dehydrogenase, aspartate aminotransferase.

[Particular features of fatty acids composition of low density lipiproteids in patients with metabolic syndrome].

The objective of the work was the study of particular features of fatty acid (FA) composition of the low density lipoproteids (LDL) in patients with metabolic syndrome (MS) (39,7+/-3,4 years). In patients with MS, compared to the healthy adults of the same age was revealed a significant increase in saturated FAs and significant decrease in unsaturated and polyunsaturated FAs in LDL particles. Significant correlation was revealed between indexes of abdominal adiposity, intima media thickness of arteria carotis communis, and level of some FAs in the LDLs.

[Possible effect of E-selectine on structure and function of arterial vessels in patients with metabolic syndrome].

Endothelial dysfunction and endothelial cells activation as it was shown in patients with ischemic heart disease play important role in atherosclerosis progression and the development of cardiovascular events. Relationship between E-selectine and functional/ structural changes of the arterial vessels in patients with metabolic syndrome was not explored. We revealed that both activation of the endothelial cells and structural/functional changes of the arterial wall mostly depend on obesity and dislipedemia and in less extent on carbohydrates metabolism disorders.

[The speed of central information processing in humans with different properties of basic nervous processes].

A speed of central information processing (CIP) and its correlation with individual-typological properties of high mental activity (HMA): by functional mobility (FMNP) and by force (FNP) of nervous processes were investigated. It was found statistically significant distinctions between the indexes of CIP in the examined groups with different levels of FMNP and FNP. Persons with the high level of FMNP and FNP were characterized by high indexes of CIP as compared with persons with low levels of typological properties of HMA.

[Efficiency of early atorvastatine treatment in patients with unstable angina].

The objective of the study is to study of the fatty acids spectr of LDL and HDL of blood plasma unstuble stenocardia (US) and increace efficiency of treatment with statines. 21 patients with US were presckribed atorvastatine with the first day of treatment Patients in control group received only basis therapy. The duration of the treatment was was 21 days.

[Changes of adenyle system indexes in patients with hypertention].

The article presents study results and comparative characteristics of the influence of foridon in tablet and 5% foridon-gel on the energetic system of patients with stage I-II hypertention. It was established that efficiency of foridon increses in case of applying 5% foridon-gel.

[Effect of etmosin on biliary motility disorders in patients with ischemic heart disease].

We have studied the influence of Etmosin medication on severity of IHD clinical presentations and comprised biliary motility in 162 patients aged 26 to 60. Dynamic echocholecystography (DECG) has been applied. The obtained data suggest using Etmosin in patients with ischemic heart disease and comprised biliary motility makes for normalizing tonus of the Odi sphincter and decreasing the rate of episodes of angina pectoris, although was not found any influence of Etmosin on gall-bladder motility.

[Effect of biliary dyskinesia on ischemic heart disease progression].

Heart syndrome features associated with pain, the structure of myocardial ischemia and heart rate derangement were studied in patients with ischemic heart disease (IHD) and concomitant biliary dyskinesia (BD). It was established that BD considerably aggravates clinical course of IHD: increase in frequency of pain and painless episodes of myocardial ischemia in patients with stable exertional angina I-II functional classes by NYHA and single supraventricular and ventricular extrasystoles.

[Clinical efficacy of corinfar retard in the treatment of patients with biliary tract dyskinesia].

Corinfar-Retard efficacy in patients with hypertonic-hyperkinetic type of biliary dyskinesia has been studied. 56 patients aged 26 to 30 had been prescribed Corinfar-Retard in 20 mg per day for 7 days. Dynamic echocholecystography has applied.

[Dynamics of immunologic indices in patients with ischemic heart disease on a course of doxazosin therapy].

The authors have studied effects of the course treatment with doxasosine, a selective alpha 1-adrenoblocker, on lipid and immunological indices in 46 male subjects with ischemic heart disease presenting with functional class I-III exertional angina. A significant improvement in indices for lipid metabolism has been shown together with absence of negative influence on parameters characterizing immunologic vigour with no worsening of manifestations of T-cellular immune deficiency. In hypercholesterinemia-free middle-aged subjects, posttreatment alterations in the peripheral blood can be regarded as a result of a positive effect on immunological reactivity.

[Endothelial dysfunction in obese hypertensive patients].

A total of 28 patients with stage II hypertensive disease (HD) were examined, their age ranging between 32 to 64 years. Of these, 17 subjects were diagnosed as having had alimentary obesity. The control group comprised 11 subjects with normal level of arterial pressure and body mass.

[Twenty four hour profile of arterial pressure in patients with hypertensive disease and concurrent obesity].

Ascertained in patients with hypertensive disease concurrent with obesity were higher values for arterial pressure (AP) over the day, absence of AP drop in the night ("non-dipper"), greater indices for the area and time over the period of twenty-four hours and in the day-time, higher rate of morning increment of AP as compared to patients with hypertensive disease without concurrent obesity.