Publications by authors named "Lyvia Moudombi"

Background: Multidrug resistance-1 (MDR1) transporter limits the intracellular accumulation of chemotherapies (paclitaxel, anthracyclines) used in breast cancer (BC) treatment. In addition to tumor cells, MDR1 is expressed on immune cell subsets in which it confers chemoresistance. Among human T cells, MDR1 is expressed by most CD8 T cells, and a subset of CD4 T helper (Th) cells.

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Article Synopsis
  • Platelets interact with neutrophils to form neutrophil-platelet aggregates (NPAs), which enhance neutrophil functions during inflammation and may worsen various inflammatory diseases, including cancer.
  • Research using advanced imaging techniques revealed that NPAs are primarily formed through platelets binding to low-density neutrophils (LDNs) in both healthy individuals and cancer patients.
  • Analyzing the genetic profile of NPAs indicated a unique molecular signature linked to neutrophil activation and worse prognosis in cancer patients, suggesting NPAs could serve as a valuable noninvasive biomarker for monitoring cancer progression.
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Prominent changes in the gut microbiota (referred to as "dysbiosis") play a key role in the development of allergic disorders, but the underlying mechanisms remain unknown. Study of the delayed-type hypersensitivity (DTH) response in mice contributed to our knowledge of the pathophysiology of human allergic contact dermatitis. Here we report a negative regulatory role of the RIG-I-like receptor adaptor mitochondrial antiviral signaling (MAVS) on DTH by modulating gut bacterial ecology.

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Disruption of endoplasmic reticulum (ER) homeostasis results in ER stress and activation of the unfolded protein response (UPR). This response alleviates cell stress, and is activated in both tumor cells and tumor infiltrating immune cells. The UPR plays a dual function in cancer biology, acting as a barrier to tumorigenesis at the premalignant stage, while fostering cancer maintenance in established tumors.

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