Publications by authors named "Lyudmila Toporkova"
Background: Praziquantel (PZQ) is the most commonly used anthelmintic drug for treating trematodiases. It was shown here that PZQ in complex with disodium glycyrrhizinate (PZQ-NaGA, in the 1:10 ratio) has higher bioavailability than PZQ alone. Our aim was to determine the effects of three-time administration of PZQ-NaGA in an experimental opisthorchiasis felinea model.
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- Millions of people globally are infected with the liver fluke Opisthorchis felineus, leading to opisthorchiasis, with praziquantel (PrzQ) as the primary treatment, though its effectiveness and side effects are concerns.
- A study showed that combining PrzQ with disodium glycyrrhizic acid (NaGA) in a 1:10 ratio allows a significant dose reduction of PrzQ while still effectively eliminating the parasite in both lab tests and in a hamster model.
- The new combination (PrzQ:GA) not only showed better overall health benefits for the host and reduced inflammation compared to PrzQ alone, but it also had no adverse effects on the animals, suggesting it could