Publications by authors named "Lyudmila Kalashnikova"
Cerebral small vessel disease (SVD) is one of the leading causes of cognitive impairment and stroke. The importance of endothelial dysfunction and high blood-brain barrier (BBB) permeability in pathogenesis, together with ischemia, is under discussion. The aim of this study was to clarify the relationship between tissue plasminogen activator (t-PA), plasminogen activator inhibitor (PAI-1), and magnetic resonance imaging (MRI) signs of SVD.
View Article and Find Full Text PDFArticle Synopsis
- CADASIL is a hereditary cerebrovascular disease linked to specific mutations in the Notch3 gene, affecting the body's small blood vessels.
- Researchers sequenced the Notch3 gene in 30 Russian patients showing CADASIL symptoms and discovered 16 mutations, including 4 that were previously unreported.
- About 60% of those suspected of having CADASIL were confirmed through genetic testing, highlighting the importance of thorough clinical assessments to identify patients likely to have these mutations.