Arabinogalactan propargyl ethers in the A-coupling reaction with aldehydes and secondary cyclic amines.

A family of novel pharmacologically prospective carbohydrate polymer aminomethylpropargyl derivatives has been synthesized by CuI-catalyzed A-coupling reaction of arabinogalactan propargyl ethers with aldehydes and secondary amines in DMSO at 23-65 °С. The arabinogalactan derivatives bearing phenyl, pyridinе, and furan moieties in combination with piperidyne, pyrrolidyne, morpholine fragments are prepared in up to 95 % yield and 0.3-2.