Publications by authors named "Lyubov A Melnikova"

Article Synopsis
  • Chemotherapy remains a primary treatment for many cancers, but side effects and drug resistance are major challenges that reduce its effectiveness over time.
  • The study explores a novel nanocarrier made of chitosan lactate nanoparticles modified with HIV-1 derived TAT peptide and hyaluronate, designed to deliver CD73 siRNA and doxorubicin (DOX) to specific cancer cells (4T1 and CT26).
  • Results show that this targeted delivery system enhances cancer cell death, reduces tumor growth, and elicits anti-tumor immune responses, making CL-TAT-HA nanoparticles a promising option for more effective cancer treatment.
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