Publications by authors named "Lyubov A Melnikova"
Blockade of CD73 using siRNA loaded chitosan lactate nanoparticles functionalized with TAT-hyaluronate enhances doxorubicin mediated cytotoxicity in cancer cells both in vitro and in vivo.
Armin Mahmoud Salehi Khesht Vahid Karpisheh Parisa Sahami Gilan Lyubov A Melnikova Angelina Olegovna Zekiy
Int J Biol Macromol
September 2021
Article Synopsis
- Chemotherapy remains a primary treatment for many cancers, but side effects and drug resistance are major challenges that reduce its effectiveness over time.
- The study explores a novel nanocarrier made of chitosan lactate nanoparticles modified with HIV-1 derived TAT peptide and hyaluronate, designed to deliver CD73 siRNA and doxorubicin (DOX) to specific cancer cells (4T1 and CT26).
- Results show that this targeted delivery system enhances cancer cell death, reduces tumor growth, and elicits anti-tumor immune responses, making CL-TAT-HA nanoparticles a promising option for more effective cancer treatment.