Publications by authors named "Lyuben Lyubenov"
Article Synopsis
- Cholesterol crystal embolism (CCE) leads to serious health issues like tissue damage and organ failure, with no specific treatments available.
- Researchers tested the idea that blocking the C5a/C5aR pathway could help reduce the harmful effects of CCE, similar to how it works in systemic vasculitis.
- Experiments in mice showed that blocking C5a or its receptor before or after cholesterol crystal injection significantly prevented kidney damage and other severe outcomes, suggesting potential for treatment in at-risk patients.
Background: Cholesterol crystal (CC) embolism causes acute kidney injury (AKI) and ischaemic cortical necrosis associated with high mortality. We speculated that sustaining the fibrinolytic system with Glu-plasminogen (Glu-Plg) could be a safe way to attenuate AKI and prevent ischaemic infarction upon CC embolism.
Methods: We induced CC embolism by injecting CC into the left kidney artery of C57BL/6J mice.
Cholesterol crystal (CC) embolism can cause acute tissue infarction and ischemic necrosis via triggering diffuse thrombotic angiopathy occluding arterioles and arteries. Neutrophils contribute to crystal-induced immunothrombosis as well as to ischemic necrosis-related necroinflammation. We speculated that CC embolism-induced acute kidney injury (AKI) would be circadian rhythm-dependent and associated with cyclic differences in neutrophil function.
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