Healthy Plant-Based Diet, Genetic Predisposition, and the Risk of Incident Venous Thromboembolism.

Background: Plant-based dietary patterns are becoming increasingly popular due to environmental and health impacts, yet there are few studies exploring the relationship between plant-based dietary patterns and venous thromboembolism (VTE) in different genetic backgrounds.

Objectives: The aim of this study was to investigate how plant-based dietary pattern and genetic susceptibility independently or jointly affect VTE and its subtypes of pulmonary embolism and deep vein thrombosis.

Methods: A total of 183,510 participants who were White British ethnicity background and free of VTE at baseline in the UK Biobank were recruited, in consideration that the selection of genetic variants for VTE was based on results of White European individuals.

MVCL-DTI: Predicting Drug-Target Interactions Using a Multiview Contrastive Learning Model on a Heterogeneous Graph.

Accurate prediction of drug-target interactions (DTIs) is pivotal for accelerating the processes of drug discovery and drug repurposing. MVCL-DTI, a novel model leveraging heterogeneous graphs for predicting DTIs, tackles the challenge of synthesizing information from varied biological subnetworks. It integrates neighbor view, meta-path view, and diffusion view to capture semantic features and employs an attention-based contrastive learning approach, along with a multiview attention-weighted fusion module, to effectively integrate and adaptively weight the information from the different views.

Validation Status of Electronic Sphygmomanometers in China: A National Survey.

Background: Although the information on the validation status of electronic sphygmomanometer (ES) devices in use in health care institutions and households is much more clinically relevant than that of ES models available on the market, it remains insufficient.

Methods: A national survey was conducted across all administrative regions of mainland China to assess the validation status of ESs. Fifty-eight cities were selected with stratification by municipality, provincial capital, and other cities, and health care institutions and households in each city were chosen by convenience to identify ES devices in use according to the study protocol.

Exploring the determinants to accept dementia screening among patients at high risk of dementia based on the theory of planned behavior: A cross-sectional study.

Background: Dementia represents a major public health challenge. Despite numerous initiatives promoting screening for early cognitive impairment to help prevent or delay its onset, participation remains limited. Moreover, there is limited evidence regarding screening intentions and predictors among populations at high risk of dementia.

Empowering Privacy Through Peer-Supervised Self-Sovereign Identity: Integrating Zero-Knowledge Proofs, Blockchain Oversight, and Peer Review Mechanism.

Frequent user data breaches and misuse incidents highlight the flaws in current identity management systems. This study proposes a blockchain-based, peer-supervised self-sovereign identity (SSI) generation and privacy protection technology. Our approach creates unique digital identities on the blockchain, enabling secure cross-domain recognition and data sharing and satisfying the essential users' requirements for SSI.

Altered zygotic gene expression caused by sperm with variants disrupts early embryonic development.

The precise mechanisms behind early embryonic arrest due to sperm-related factors and the most effective strategies are not yet fully understood. Here, we present two cases of male infertility linked to novel variants, associated with oligoasthenoteratozoospermia (OAT) and early embryonic arrest. To investigate the underlying mechanisms and promising therapeutic approaches, knock-in and knock-out mice were generated.

An Unusual Semiquinone-mediated Self-catalysis Redox Mechanism for the Reaction between Halohydroquinones and N-Substituted Hydroxamic acids.

We found recently that a C-C bonding phenyl-quinone product was produced with high yield (96%) from the reaction between 2,5-dichloro-1,4-Benzoquinone (DCBQ) and N-phenylbenzohydroxamic acid (N-PhBHA) via an unusual Claisen rearrangement mechanism, accompanied with the concurrent formation of the minor byproducts amide (N-phenylBenzamide, N-PhBA; only 2% yield) and hydroxychloroquinone (2% yield). Surprisingly, when DCBQ was replaced with its reduced form 2,5-dichloro-1,4-hydroquinone (DCHQ), no C-C bonding product was detected, whereas N-PhBA (83% yield) and hydroxychloroquinone (80% yield) became the predominant products, indicating a dramatic mechanistic shift. The ascorbate reduction experiment suggested that it was not DCHQ itself, but its corresponding semiquinone radical, that directly reacts with N-PhBHA.

Examination of the Bioavailability and Bioconversion of Wheat Bran-Bound Ferulic Acid: Insights into Gastrointestinal Processing and Colonic Metabolites.

The postingestion journey and bioconversion of wheat bran-bound ferulic acid, a known beneficial phytochemical, remain insufficiently understood. This study aims to systematically investigate its bioaccessibility, bioavailability, excretion, and colonic metabolism, both and . Initial analysis confirmed the abundance and bioactivity of ferulic acid in wheat bran.

A hybrid attention generative adversarial network for Chinese landscape painting.

In traditional Chinese painting, the genre of landscapes is unique and universally valued. For an untrained person to achieve such results is very difficult, requiring mastery of such things as brushwork, composition, and color. In this paper, we propose HA-GAN to transform sketches into Chinese landscape paintings, a new GAN-based framework that builds upon a hybrid attention generator and a discriminator.

An analytical solution for internal forces of shallow circular low-to-vacuum tunnel linings in soft soils.

This paper presents an analytical solution derived with force method for the internal forces in the ring lining of maglev train tunnels, which are typically in a circular section and shallowly buried with low vacuum air pressure in the lining. The model incorporates the vacuum pressure induced by the differences in air pressures outside and inside the lining, and the vacuum pressure is assumed to be the active load exerting to the outside of the lining. The model assumes the vertical overburden acting on the lining is proportional to the soil depth at every particular point along the tunnel lining circumference.

DSE-HNGCN: Predicting the frequencies of drug-side effects based on heterogeneous networks with mining interactions between drugs and side effects.

Evaluating the frequencies of drug-side effects is crucial in drug development and risk-benefit analysis. While existing deep learning methods show promise, they have yet to explore using heterogeneous networks to simultaneously model the various relationship between drugs and side effects, highlighting areas for potential enhancement. In this study, we propose DSE-HNGCN, a novel method that leverages heterogeneous networks to simultaneously model the various relationships between drugs and side effects.

Ultrastructure of the ejaculatory duct of Terrobittacus implicatus (Mecoptera: Bittacidae).

The unique mating behavior of Bittacidae has been extensively studied, yet the mechanisms underlying internal sperm transport and temporary storage before mating remain enigmatic. Herein, we aim to elucidate these mechanisms by investigating the fine structure of the ejaculatory duct, which serves for sperm transport and temporary storage. The ultrastructure of the ejaculatory duct of Terrobittacus implicatus (Mecoptera: Bittacidae) was examined by light and transmission electron microscopy for the first time in this study.

Transmissible topological edge states based on Su-Schrieffer-Heeger photonic crystals with defect cavities.

Topological photonic crystals have great potential in the application of on-chip integrated optical communication devices. Here, we successfully construct the on-chip transmissible topological edge states using one-dimensional Su-Schrieffer-Heeger (SSH) photonic crystals with defect cavities on silicon-on-insulator slab. Different coupling strengths between the lateral modes and diagonal modes in photonic crystal defect cavities are used to construct the SSH model.

PACS2/CPT1A/DHODH signaling promotes cardiomyocyte ferroptosis in diabetic cardiomyopathy.

Objectives: The pathophysiology of diabetic cardiomyopathy (DCM) is a phenomenon of great interest, but its clinical problems have not yet been effectively addressed. Recently, the mechanism of ferroptosis in the pathophysiology of various diseases, including DCM, has attracted widespread attention. Here, we explored the role of PACS2 in ferroptosis in DCM through its downregulation of PACS2 expression.

Efficacy of composite bacterial deodorant constructed with Camellia sinensis and its in-situ deodorization mechanism on pig manure.

Here, we constructed a novel bacterial deodorant (BD) composed of Delftia tsuruhatensis, Paracoccus denitrificans, Pediococcus acidilactici, and Bacillus velezensis. The BD alone removed 64.84 % of NH, 100 % of HS, and 63.

A Multifunctional Nanodrug Co-Delivering VEGF-siRNA and Dexamethasone for Synergistic Therapy in Ocular Neovascular Diseases.

Introduction: Oxidant stress, abnormal angiogenesis, and inflammation are three key factors contributing to the development of ocular neovascular diseases (ONDs). This study aims to develop a multifunctional nanodrug, DEX@MPDA-Arg@Si (DMAS), which integrates mesoporous polydopamine, vascular endothelial growth factor (VEGF)-siRNA, and dexamethasone (DEX) to address these therapeutic targets.

Methods: Physicochemical properties of DMAS were measured using transmission electron microscopy and a nanoparticle size analyzer.

Electroacupuncture combined with NSCs-Exo alters the response of hippocampal neurons in a chronic unpredictable mild stress paradigm in ovx rats.

Electroacupuncture (EA) is a form of Traditional Chinese Medicine (TCM) that combines acupuncture with microcurrents mimicking the body's bioelectricity to prevent and treat diseases. Previous studies have demonstrated its antidepressant-like effects in chronic unpredictable mild stress (CUMS)-induced ovariectomy (OVX) rats. Neural stem cell-derived exosomes (NSCs-Exo) are heterogeneous and targeted, effectively promoting nerve regeneration and repairing neuronal damage, while potentially conveying the effects of EA.

Insights into the Therapeutic Potential of Active Ingredients of in Combatting Sarcopenia: An In Silico Approach.

Sarcopenia is a systemic medical disorder characterized by a gradual decline in muscular strength, function, and skeletal muscle mass. Currently, there is no medication specifically approved for the treatment of this condition. Therefore, the identification of new pharmacological targets may offer opportunities for the development of novel therapeutic strategies.

Weight-adjusted waist index associated with bone mineral density in rheumatoid arthritis patients: a cross-sectional study.

The research examined the association between weight-adjusted waist index (WWI) and bone mineral density (BMD) in individuals with rheumatoid arthritis, considering the impact of obesity on bone health. The association between WWI and BMD was examined utilizing weighted linear regression and smoothed curve fitting with data from NHANES 2005-2010, 2013-2014, and 2017-2018. Subgroup analysis verified the stability of the results.

Druggable targets for Parkinson's disease: transcriptomics based Mendelian randomization study.

Parkinson's disease (PD) is a prevalent neurodegenerative disorder. Currently available drugs for PD, can only relieve the symptoms of PD, but cannot prevent the progression of the disease and have serious side effects. Other new druggable therapeutic targets for PD are needed.

Lignocellulose degradation and temperature adaptation mechanisms during composting of mushroom residue and wood chips at low temperature with inoculation of psychrotolerant microbial agent.

Low ambient temperature become the limiting factor of composting in cold regions, thus hindering the recycle of agricultural and forestry wastes. In this study, the composting of mushroom residue and wood chips (MRWC) under low temperature was successfully implemented with inoculation of psychrotolerant cellulolytic microbial agent. Composting entered thermophilic stage on third day and the peak temperature reached to 66.

Impacts of plastic pollution on soil-plant properties and greenhouse gas emissions in wetlands: A meta-analysis.

Plastic pollution in wetlands has recently emerged as an urgent environmental problem. However, the impacts of plastic contamination on soil-plant properties and greenhouse gas (GHG) emissions in wetlands remain unclear. Thus, this study conducted a meta-analysis based on 44 study sites to explore the influence of plastic pollution on soil physicochemical variables, soil microorganisms, enzyme activity, functional genes, plant characteristics, and GHG emissions (CO, CH, and NO) in different wetland types.

Multi-Channel Signals in Dynamic Force-Clamp Mode of Microcantilever Sensors for Detecting Cellular Peripheral Brush.

The development of numerous diseases, such as renal cyst, cancer, and viral infection, is closely associated with the pathological changes and defects in the cellular peripheral brush. Therefore, it is necessary to develop a potential new method to detect lesions of cellular peripheral brush. Here, a piecewise linear viscoelastic constitutive model of cell is established considering the joint contribution of the peripheral brush and intra-cellular structure.

Development and evaluation of a panel of newly screened Y chromosome InDels for inferring paternal ancestry information in Southwest China.

Y-InDels (insertions/deletions) are genetic markers which are extremely understudied. It is unknown whether this type of markers can be utilized for genetic ancestry inference. We have developed an innovative Y chromosome ancestry inference system tailored for forensic applications.