Publications by authors named "Lyse Bordier"
Article Synopsis
- The study investigates the varying glycaemic profiles in individuals with type 1 diabetes to better understand their complexities.
- Using a unique methodology and the DDRTree algorithm, researchers identified seven distinct glycaemic phenotypes among 618 participants.
- The findings suggest that relying solely on traditional metrics may overlook important subtleties of glycaemic management, emphasizing the need for more tailored strategies in treatment.*
Diabetic neuropathy is a frequent and severe degenerative complication of diabetes. The diagnosis is easily performed in painful symptomatic patients. Sensitivity disorders responsible for numbness, tingling, and loss of feeling are part and parcel of diabetic foot syndrome and require investigation in view of preventing trophic ulcers.
View Article and Find Full Text PDFBackground: Little is known about clinical events occurring in older patients with type 2 diabetes mellitus according to their therapeutic modalities based on the prescription of insulin and/or oral antidiabetic drugs.
Objective: The aim of this study was to compare the complications of diabetes and geriatric alterations that occurred according to three therapeutic modalities prescribed over 5 years.
Methods: A total of 616 patients from the GERODIAB cohort (mean age 77.
The care of elderly diabetic patients has now become a real public health issue due to the increase in the number of patients. In this population, complications are more serious and are intertwined with more specifically gerontological issues. Treatment goals should be individualized based on the patient's clinical presentation.
View Article and Find Full Text PDFIntroduction: Combining basal insulin (BI) with glucagon-like peptide-1 receptor agonist (GLP-1RA) is recognized as a relevant option to optimize glucose control in type 2 diabetes (T2D). The EASY real-world study aimed to evaluate the modalities of initiation and the effectiveness of the insulin Degludec plus Liraglutide (IDegLira) fixed-ratio combination in the French health care system.
Methods: A retrospective analysis included all patients with T2D and prior injectable therapy (GLP1-RA and/or insulin) who started treatment with IDegLira from September 2016 to December 2017 in 11 French diabetes centers.
Article Synopsis
- The study aimed to determine if diabetes is a risk factor for severe COVID-19 outcomes, independent of age and other health conditions, as diabetes is often seen in older individuals.
- Conducted as part of the CORONADO initiative, the research matched 2210 COVID-19 patients with and without diabetes by age, sex, and admission date, assessing outcomes like death and the need for invasive mechanical ventilation.
- Results showed that diabetes patients had higher rates of adverse outcomes within both 7 and 28 days of hospital admission, indicating that diabetes is a significant risk factor for severe COVID-19 complications regardless of age and comorbidity.
Article Synopsis
- - The study analyzed the impact of cardiovascular disease (CVD) and nontraumatic lower-limb amputation (LLA) on mortality risk in individuals with type 1 diabetes, using data from three prospective cohorts.
- - Out of 1169 participants, those with a history of CVD or LLA had double or more than double the risk of death compared to those without these conditions, with even higher risk for individuals with both conditions.
- - Both CVD and LLA were found to similarly reduce life expectancy in these patients, with those having both conditions facing a loss of over seven years of life compared to those without any health issues.
Adrenogenital syndrome is commonly associated with a deficiency in 21-hydroxylase but can be present in other rare enzymatic blocks. We report here the case of a 31-year-old man who presented with bilateral painful testicle lesions leading to bilateral partial orchiectomy as they were suspected for malignancy. These lesions were finally identified as benign testicle adrenal rest tumors (TARTs), and the patient was actually belatedly diagnosed with primary adrenal insufficiency due to 2 mutations of the gene encoding the cholesterol side-chain cleavage enzyme (P450scc); the mutations were 940G > A (p.
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- This study examined how having metabolic and bariatric surgery (MBS) affects the outcomes of patients with type 2 diabetes (T2D) and severe obesity who are hospitalized for COVID-19.
- Researchers matched patients with a history of MBS to those without, focusing on their age, sex, and BMI at the time of either surgery or COVID-19 admission.
- Results showed that patients with MBS had significantly lower rates of invasive mechanical ventilation or death within 7 and 28 days following admission compared to those without MBS, suggesting better COVID-19 prognosis for MBS patients.
Article Synopsis
- The study examined sex differences in severe outcomes of COVID-19 among adults with diabetes, analyzing data from 2,380 hospitalized patients.
- Findings revealed that females had a lower risk of invasive mechanical ventilation, death, and ICU admission compared to males, although this female advantage was less evident in overall in-hospital mortality.
- The research highlighted specific predictors of death linked to sex, emphasizing the need for tailored COVID-19 management strategies based on biological differences.
Article Synopsis
- The CORONADO study examines outcomes in diabetic patients hospitalized due to COVID-19, focusing on hospital discharge and death rates within 28 days of admission.
- The study analyzed data from 2,796 patients, revealing that 50.2% were discharged and 20.6% died; factors influencing discharge included younger age and metformin use, while complications and severity indicators were linked to a higher risk of death.
- The findings aim to identify key prognostic factors to guide clinical decision-making for diabetic patients during the pandemic.
Aim: To investigate the association between routine use of dipeptidyl peptidase-4 (DPP-4) inhibitors and the severity of coronavirus disease 2019 (COVID-19) infection in patient with type 2 diabetes in a large multicentric study.
Materials And Methods: This study was a secondary analysis of the CORONADO study on 2449 patients with type 2 diabetes (T2D) hospitalized for COVID-19 in 68 French centres. The composite primary endpoint combined tracheal intubation for mechanical ventilation and death within 7 days of admission.
Article Synopsis
- Offloading is essential for treating diabetic foot ulcers (DFU), and a new custom removable offloading device was evaluated for its effectiveness in a multicenter study involving 112 adults with neuropathic DFU.
- Participants were randomly assigned to use the new device or conventional offloading devices; however, healing rates after 3 months were similar in both groups, with around 33%-35% achieving full healing.
- The new device had a higher rate of adverse events and was worn less frequently than conventional options, leading to the conclusion that it does not provide superior healing benefits for DFU compared to existing treatments.
Background: Lipohypertrophy (LH) is highly prevalent and is potentially harmful to insulin-injecting patients.
Methods: In this study, we assessed the impact of injection technique (IT) education, including use of a 4-mm pen needle on insulin-treated patients with clinically observed LH in a randomized, controlled, prospective multicenter study in France with follow-up of 6 months. Intensive education and between-visit reinforcement were given to the intervention group.
Background: Sudomotor dysfunction is one of the earliest pathophysiologic abnormalities in diabetes. Sudoscan™ (Impeto Medical, Paris, France) was developed as a noninvasive, rapid, and quantitative assessment of sudomotor function and has been shown to be sensitive in the detection of neuropathy. This global collaborative analysis aimed to establish reference values in healthy subjects of different ethnic groups, age, and gender, to define factors potentially affecting results, and to provide standardization of the methodology.
View Article and Find Full Text PDFThe 2008-year was full of learning experience and suspense in diabetologia. The past studies, UKPDS in type 2 diabetic patients and DCCT in type 1 diabetic patients have shown that intensive treatment during a short period did reduce the incidence of microvascular events and in the long term, the incidence of macrovascular events linked to diabetes. The conclusions of recent studies quote, from ACCORD, an increased mortality in the type 2 diabetic patients using intensive therapy, from ADVANCE, a reduction of microvascular complications and from VADT, no effect.
View Article and Find Full Text PDFThe disorder now known as the "metabolic syndrome "was first recognized 50 years ago, but the use of various definitions led to confusion over its real nature. The metabolic syndrome is directly linked to android obesity, which reflects insulin resistance; it lies at the root of all associated risk factors and is a forerunner of type 2 diabetes. Screening is based on systematic waist measurement, taking ethnic origin into account.
View Article and Find Full Text PDFIntroduction: Microalbuminuria is an early indication of diabetic nephropathy in patients with Type 1 diabetes and a marker of cardiovascular in patients with type 2 diabetes. It must therefore be assessed annually in these patients. We sought to determine whether semiquantitative determination of proteinuria with urinary dipsticks was useful for this purpose.
View Article and Find Full Text PDFDEFINITION OF HYPOURICEMIA: Hypouricemia (serum uric acid less than 120 micro mol/l) is a biological abnormality often discovered accidentally and with a low prevalence depending on its permanent or transitory nature ranging from 0.15 to 3.38%.
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