Modulatory effects of cognitive exertion on regional functional connectivity of the salience network in women with ME/CFS: A pilot study.

Background: A common symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is post-exertional malaise (PEM). Various brain abnormalities have been observed in patients with ME/CFS, especially in insular and limbic areas, but their link with ME/CFS symptoms is still unclear. This pilot study aimed at investigating the association between PEM in ME/CFS and changes in functional connectivity (FC) of two main networks: the salience network (SN) and the default-mode network (DMN).

A near real-time system for continuously monitoring airborne subtilisin-type enzymes in the industrial atmosphere.

We describe the development and validation of a portable system comprising an air sampler coupled to an automated flow injection analysis device. The system is able to monitor airborne concentrations of subtilisin-type enzymes in the workplace atmosphere on a continuous basis. Sampling is in two stages: using a sampling head that is designed to mimic human respiration at approx.

Identification of novel mammalian squalene synthase inhibitors using a three-dimensional pharmacophore.

Squalene synthase (E.C. 2.