Improvements to mood, stress and loneliness following 12-week multivitamin supplementation in older adults: a randomised, placebo-controlled, trial.

Background: Research has indicated the potential for multivitamin-mineral (MVM) supplementation to improve aspects of wellbeing and cognitive function in older adults via a range of biological mechanisms. However, outside of cognitive function and mood, this research rarely assesses other outcomes that are pertinent to the daily lives of older adults. The current study aimed to investigate the effectiveness of a MVM supplement on meaningful outcomes of everyday functioning in older adults.

Evaluation of in vivo staging of amyloid deposition in cognitively unimpaired elderly aged 78-94.

Amyloid-beta (Aβ) deposition is common in cognitively unimpaired (CU) elderly >85 years. This study investigated amyloid distribution and evaluated three published in vivo amyloid-PET staging schemes from a cognitively unimpaired (CU) cohort aged 84.9 ± 4.

The Effects of COVID-19 Lockdown on Health and Psychosocial Functioning in Older Adults Aged 70 and Over.

The COVID-19 pandemic led to a state-imposed lockdown in the UK; there are many psychosocial consequences of pandemics, with older adults potentially at an increased risk. The current study assessed psychosocial functioning in a sample of older adults in the UK with baseline data collected pre-lockdown and follow-up 12 weeks later during lockdown. Thus, allowing investigation of the effect of COVID-19 and associated lockdown on psychosocial well-being.

Scores Obtained from a Simple Cognitive Test of Visuospatial Episodic Memory Performed Decades before Death Are Associated with the Ultimate Presence of Alzheimer Disease Pathology.

Background: Community- or population-based longitudinal studies of cognitive ability with a brain donation end point offer an opportunity to examine relationships between pathology and cognitive state prior to death. Discriminating the earliest signs of dementing disorders, such as Alzheimer disease (AD), is necessary to undertake early interventions and treatments.

Methods: The neuropathological profile of brains donated from The University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age, including CERAD (Consortium to Establish a Registry for Alzheimer's Disease) and Braak stage, was assessed by immunohistochemistry.

Location tracking: views from the older adult population.

Background: there has been a rise in the use of social media applications that allow people to see where friends, family and nearby services are located. Yet while uptake has been high for younger people, adoption by older adults is relatively slow, despite the potential health and social benefits. In this paper, we explore the barriers to acceptance of location-based services (LBS) in a community of older adults.

Exploring patterns of daily physical and sedentary behaviour in community-dwelling older adults.

Background: recent evidence suggests that the interaction between periods of sedentary and activity behaviour is important for health; providing distinctive information to assessment of activity alone. This study quantified activity and sedentary behaviour in older, community-dwelling adults.

Methods: fifty-six community-dwelling older adults with an average age 79 (SD) years wore an ActivPAL accelerometer for 7 days and were assessed for a range of motor, cognitive and affective characteristics.

Developing a self-reported comorbidity index to predict mortality of community-dwelling older adults.

Current common comorbidity measures have poor to moderate predictive validity of mortality of community-dwelling older adults. Hence, our aim is to develop a simpler resource-efficient self-reported comorbidity index in the prediction of survival. 113 older adults in Greater Manchester, United Kingdom attended a routine medical examination whereby information gathered was used to construct Charlson Comorbidity Index (CCI).

Further analyses of the effects of practice, dropout, sex, socio-economic advantage, and recruitment cohort differences during the University of Manchester longitudinal study of cognitive change in old age.

A sample of 4,314 volunteers who, when first recruited, were aged from 41 to 93 years were quadrennially tested from 2 to 4 occasions during the next 4 to 20 years on the Cattell Culture Fair intelligence test, 2 tests of information-processing speed, the Wechsler Adult Intelligence Scale (WAIS) vocabulary test, and 3 memory tests. After significant effects of practice, sex, demographics, socio-economic advantage, and recruitment cohort had been identified and considered, performance on all tests declined with age. These age-related declines accelerated for the Cattell and WAIS, 2 tests of information speed, and 2 of the memory tests.

Concordance of Cornell medical index self-reports to structured clinical assessment for the identification of physical health status.

Self-reported questionnaires are frequently used to assess health status in epidemiological studies. The Cornell medical index is one such tool used to determine the presence of physical and psychiatric illness but its accuracy and value have been questioned. In this study we have assessed the ability of the CMI to predict health status in two separate patient populations (n = 101, 88) by comparison to a structured medical assessment based on the SENIEUR protocol by two physicians.

Practice and drop-out effects during a 17-year longitudinal study of cognitive aging.

Interpretations of longitudinal studies of cognitive aging are misleading unless effects of practice and selective drop-out are considered. A random effects model taking practice and drop-out into account analyzed data from four successive presentations of each of two intelligence tests, two vocabulary tests, and two verbal memory tests during a 17-year longitudinal study of 5,899 community residents whose ages ranged from 49 to 92 years. On intelligence tests, substantial practice effects counteracted true declines observed over 3 to 5 years of aging and remained significant even with intervals of 7 years between successive assessments.

Do clever brains age more slowly? Further exploration of a nun result.

Recent epidemiological evidence suggests that individuals who have higher levels of mental ability in youth experience a slower cognitive decline as they grow old. In a sample of 3,263 Newcastle residents, average scores on a vocabulary test (Raven's 1965 'Mill Hill A') did not vary, while average scores on a test of fluid mental ability (the Heim, 1970, AH 4 (1) group intelligence test) sharply declined with age from 49 to 92 years. In young adults, Mill Hill A scores are good proxies for AH 4 (1) scores.

Effects of death within 11 years on cognitive performance in old age.

Six different cognitive tests and the Heck Depression Inventory (BDI) were given to 3,572 active community residents aged 49 to 93 years. Causes of death were ascertained for 443 who died between 36 and 3,903 days later. Subsequent survival predicted test scores during the 3,903 days and independently during Days 36 to 1,826 and Days 1,827 to 3,903.