Publications by authors named "Lynn Greenblatt"
Bioorg Med Chem
March 2008
Article Synopsis
- Kv1.1 channels are found in various brain and spinal cord regions and contribute to neuron hyperpolarization when expressed alone, but co-expression with Kvbeta1 switches them to a fast inactivating current, increasing neuron excitability.
- A yeast two-hybrid screen was used to find compounds that prevent Kv1.1 inactivation by Kvbeta1, identified as 'disinactivators,' which also showed potential in reducing seizure activity in mice.
- These disinactivators work through various mechanisms, likely interacting with the Kvbeta1 N-terminus or its binding site on Kv1.1, offering a possible treatment strategy for conditions like epilepsy and neuropathic pain.
