Cranial base, maxillary and mandibular morphology in Down syndrome.

Objective: To test the null hypothesis that there is no difference between craniofacial measurements of individuals with Down syndrome (DS) and normal controls.

Materials And Methods: A cephalometric analysis including additional landmarks and measurements to study specific craniofacial features was undertaken on pretreatment cephalograms of 25 patients with DS (12 male, 13 female; mean age 15.1 years) treated at The Hospital for Sick Children, Toronto.