Publications by authors named "Lynn Cornell"

The XVI-th Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from 19th-23rd September 2022, as a joint meeting with the Canadian Society of Transplantation. To mark the 30 anniversary of the first Banff Classification, pre-meeting discussions were held on the past, present, and future of the Banff Classification. This report is a summary of the meeting highlights that were most important in terms of their effect on the Classification, including discussions around microvascular inflammation and biopsy-based transcript analysis for diagnosis.

View Article and Find Full Text PDF
Article Synopsis
  • VEXAS syndrome is a disease caused by a mutation that affects many organs, including the kidneys, which wasn't well studied before.
  • In a study of 81 men with this syndrome, 25% developed kidney problems, often coming back multiple times.
  • The research found that older age and certain test results can affect how quickly kidney problems start and that a specific type of kidney damage is common among patients.
View Article and Find Full Text PDF

Introduction: IgG4-related disease (IgG4-RD) is a systemic immune-mediated disease that can involve nearly any organ. IgG4-RD can affect the kidney in different disease patterns, collectively referred to as IgG4-related kidney disease (IgG4-RKD).

Methods: We conducted a tissue-based cohort study with clinicopathological correlation in 125 patients with IgG4-RKD.

View Article and Find Full Text PDF

Rationale & Objective: Crystalglobulinemia is a rare syndrome characterized by intravascular crystallization of monoclonal immunoglobulins (MIg). Data on kidney involvement are limited to case reports. This series characterizes the clinicopathologic spectrum of crystalglobulin-induced nephropathy (CIN).

View Article and Find Full Text PDF
Article Synopsis
  • - The XVIth Banff meeting in September 2022 marked the 30th anniversary of the Banff classification and focused on improving the classification system for kidney transplantation, resulting in two new publications.
  • - A group of 16 experts reviewed the manuscripts, highlighting the addition of two new entities that enhance the classification and enable better understanding of kidney transplant biopsies and their clinical implications.
  • - Despite the improvements, the Banff classification's complexity may still limit its use, necessitating further evidence and clinical trials to support the incorporation of molecular diagnostics and to refine diagnostic approaches for various types of kidney rejection.
View Article and Find Full Text PDF

Background: Microvascular inflammation (MVI) is a key feature of antibody-mediated rejection (AMR) among patients with HLA donor-specific antibody (DSA), but MVI at AMR thresholds (Banff glomerulitis [g] + peritubular capillaritis [ptc] score ≥ 2) without DSA has been increasingly recognized. We aimed to determine the incidence of MVI among highly sensitized kidney transplant recipients without DSA.

Methods: We performed a single-center, retrospective, matched cohort study comparing outcomes of kidney transplant recipients with cPRA ≥90% with preexisting DSA (n = 49), cPRA ≥90% without preexisting DSA (n = 47), and matched controls with cPRA = 0 without preexisting DSA (n = 49).

View Article and Find Full Text PDF

Objectives: ChatGPT (OpenAI, San Francisco, CA) has shown impressive results across various medical examinations, but its performance in kidney pathology is not yet established. This study evaluated proficiencies of GPT-4 Vision (GPT-4V), an updated version of the platform with the ability to analyze images, on kidney pathology questions and compared its responses with those of nephrology trainees.

Methods: Thirty-nine questions (19 text-based questions and 20 with various kidney biopsy images) designed specifically for the training of nephrology fellows were employed.

View Article and Find Full Text PDF

IgG4-related kidney disease (IgG4-RKD) encompasses all forms of kidney disease that are part of IgG4-related disease (IgG4-RD). First recognized as IgG4-related tubulointerstitial nephritis (IgG4-TIN), and then IgG4-related membranous glomerulonephritis (IgG4-MGN), we now recognize additional patterns of interstitial nephritis, glomerular disease, and vascular disease that can be seen as part of IgG4-RKD. The clinical presentation is variable and can include acute or chronic kidney injury, proteinuria or nephrotic syndrome, mass lesion(s), and obstruction.

View Article and Find Full Text PDF

In kidney transplantation, day-zero biopsies are used to assess organ quality and discriminate between donor-inherited lesions and those acquired post-transplantation. However, many centers do not perform such biopsies since they are invasive, costly and may delay the transplant procedure. We aim to generate a non-invasive virtual biopsy system using routinely collected donor parameters.

View Article and Find Full Text PDF

The XVI-th Banff Meeting for Allograft Pathology was held at Banff, Alberta, Canada, from 19th to 23rd September 2022, as a joint meeting with the Canadian Society of Transplantation. To mark the 30th anniversary of the first Banff Classification, premeeting discussions were held on the past, present, and future of the Banff Classification. This report is a summary of the meeting highlights that were most important in terms of their effect on the Classification, including discussions around microvascular inflammation and biopsy-based transcript analysis for diagnosis.

View Article and Find Full Text PDF

The XVIth Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from September 19 to 23, 2022, as a joint meeting with the Canadian Society of Transplantation. In addition to a key focus on the impact of microvascular inflammation and biopsy-based transcript analysis on the Banff Classification, further sessions were devoted to other aspects of kidney transplant pathology, in particular T cell-mediated rejection, activity and chronicity indices, digital pathology, xenotransplantation, clinical trials, and surrogate endpoints. Although the output of these sessions has not led to any changes in the classification, the key role of Banff Working Groups in phrasing unanswered questions, and coordinating and disseminating results of investigations addressing these unanswered questions was emphasized.

View Article and Find Full Text PDF
Article Synopsis
  • The Banff Digital Pathology Working Group (DPWG) was created to build a digital pathology repository, develop AI models for analyzing images, and enhance collaboration through videoconferencing.
  • During meetings, various AI support systems for transplantation pathology were reviewed, and the DIAGGRAFT challenge for kidney transplants was proposed, which includes assessing biopsies and refining Banff scoring algorithms.
  • A survey showed that nearly half of the respondents already have access to servers for a digital pathology repository, with plans to create a pilot repository and continue collaboration through the upcoming competition/trial.
View Article and Find Full Text PDF

Atypical antiglomerular basement membrane (anti-GBM) nephritis can be defined as linear GBM staining for monotypic or polytypic immunoglobulin (Ig) by immunofluorescence (IF) without a diffuse crescentic pattern. We describe the clinicopathologic features of 6 patients (18 biopsies) in this first series of recurrent atypical anti-GBM nephritis after kidney transplantation. Recurrent glomerulonephritis occurred at a mean of 3.

View Article and Find Full Text PDF

Introduction: Lysozyme-associated nephropathy (LyN), a rare cause of kidney injury in patients with chronic myelomonocytic leukemia (CMML), has not been well described to date. We report the clinicopathologic spectrum of LyN from a multi-institutional series.

Method: We identified 37 native kidney biopsies with LyN and retrospectively obtained clinicopathologic data.

View Article and Find Full Text PDF

COVID-19 is a systemic disease, and the kidney is one of the target organs of infection. Kidney injury is common and can occur in up to 40% of patients. Several glomerular diseases have been reported in association with COVID-19.

View Article and Find Full Text PDF
Article Synopsis
  • Researchers are investigating non-invasive biomarkers to diagnose immune checkpoint inhibitor-associated acute tubulointerstitial nephritis (ICI-nephritis), focusing on markers of immune dysregulation linked to CTLA4 deficiency.
  • The study compared sIL-2R levels and cell-based markers from patients with ICI-nephritis against various control groups, revealing that sIL-2R levels were significantly elevated in patients with ICI-nephritis.
  • A specific sIL-2R cutoff of 1.75-fold above the normal limit was found to be a strong indicator for diagnosing ICI-nephritis.
View Article and Find Full Text PDF

Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is the second most common monoclonal gammopathy of renal significance. Rates of progression to kidney failure as well as rates of recurrence after kidney transplantation are high, especially in the absence of treatment. Treatment is usually targeted toward the abnormal clone, but even in the absence of an identifiable clone, empiric treatment is still recommended to avoid worsening prognosis.

View Article and Find Full Text PDF

Background: Recent studies identified underlying genetic causes in a proportion of patients with various forms of kidney disease. In particular, genetic testing reclassified some focal segmental glomerulosclerosis (FSGS) cases into collagen type 4 (COL4)-related nephropathy. This knowledge has major implications for counseling prospective transplant recipients about recurrence risk and screening biologically related donors.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionaj1u86di8unh0j3getgq1r8eocbmiud1): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once