Publications by authors named "Lynley M Doonan"
Article Synopsis
- * The Hsp104 chaperone in yeast helps break down these problematic proteins, including apolipoprotein B and a mutated form of the cystic fibrosis protein, suggesting that Hsp104 aids in their degradation.
- * Experiments showed that unstable protein variants were less soluble and required Hsp104 for removal from the ER, while stable proteins could exist without it; this raises questions about how similar processes occur in human cells, which lack Hsp104.
Can modulators of apolipoproteinB biogenesis serve as an alternate target for cholesterol-lowering drugs?
Biochim Biophys Acta Mol Cell Biol Lipids
July 2018
Understanding the molecular defects underlying cardiovascular disease is necessary for the development of therapeutics. The most common method to lower circulating lipids, which reduces the incidence of cardiovascular disease, is statins, but other drugs are now entering the clinic, some of which have been approved. Nevertheless, patients cannot tolerate some of these therapeutics, the drugs are costly, and/or the treatments are approved for only rare forms of disease.
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