Pharmacokinetics of extended-release buprenorphine in female Yorkshire swine (Sus scrofa domestica).

Objective: To determine the pharmacokinetics of extended-release buprenorphine (XRB) in adult swine. We hypothesized that after a single SC administration of XRB in swine, buprenorphine plasma concentrations would be at or above the therapeutic threshold of 0.1 ng/mL and would not result in major injection site reactions.