Publications by authors named "Lyndsey McRae"
Article Synopsis
- Outcomes from vagus nerve stimulation (VNS) improve over time in children with drug-resistant epilepsy, but the benefits of deep brain stimulation (DBS) versus continued VNS optimization were unclear.
- A study involving 18 children aged 8-17 showed that adding DBS after a year of ineffective VNS led to significantly greater seizure reduction (51.9% vs. 12.3%).
- While DBS resulted in fewer bothersome seizures, it did not improve the overall quality of life, suggesting that earlier consideration of DBS could be beneficial for children not responding to VNS.
Article Synopsis
- Most neonatal and infantile-onset epilepsies are thought to have genetic causes, and early genetic testing could help improve treatment and outcomes for affected infants.
- The Gene-STEPS study involved four pediatric centers across Australia, Canada, the UK, and the USA, where researchers collected blood samples and clinical data from infants under 12 months old who had new-onset epilepsy or complex febrile seizures.
- Out of 100 enrolled infants, 43 (43%) received genetic diagnoses through rapid genome sequencing, showing the effectiveness of this method in identifying underlying genetic factors.
PICU hospitalization can have a profound impact on child survivors and their families. There is limited research on children's long-term recovery within the context of the family following critical illness. This study aimed to explore children's and parents' perceptions of long-term psychological and behavioral responses within the context of the family one year following PICU hospitalization.
View Article and Find Full Text PDFBackground: Sleep disturbance and fatigue are common and distressing pediatric cancer-related outcomes. Sleep hygiene education and relaxation techniques are recommended to improve sleep in healthy children and adult cancer survivors. No studies have tested these interventions to improve sleep and fatigue for children with acute lymphoblastic leukemia (ALL) in the home setting.
View Article and Find Full Text PDFAn optimal search filter for retrieving systematic reviews and meta-analyses.
BMC Med Res Methodol
April 2012
Background: Health-evidence.ca is an online registry of systematic reviews evaluating the effectiveness of public health interventions. Extensive searching of bibliographic databases is required to keep the registry up to date.
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