3D-printed polyurethane immunoisolation bags with controlled pore architecture for macroencapsulation of islet clusters encapsulated in alginate gel.

Diabetes mellitus is a fast-growing chronic metabolic condition caused by insulin deficiency or resistance, leading to lifelong insulin use. It has become one of the world's most difficult non-communicable diseases. The goal of this study was to view the effectiveness of the combined method of macro- and microencapsulation for islet transplantation.

Designer injectable matrices of photocrosslinkable carboxymethyl cellulose methacrylate based hydrogels as cell carriers for gel type autologous chondrocyte implantation (GACI).

Gel-type autologous chondrocyte implantation (GACI) is the fourth-generation therapeutic strategy that has been introduced to address the limitations of earlier generation strategies, especially problems related to cell leakage upon implantation and loss of chondrocyte functionality owing to the dedifferentiation of cells in culture and fibrocartilage formation. In GACI, an injectable gel system is used, which acts as the cell carrier. However, the maintenance of the morphology and redifferentiation of chondrocytes with appropriate biofunctionality are major challenges in this technique.

Advancement of Scaffold-Based 3D Cellular Models in Cancer Tissue Engineering: An Update.

The lack of traditional cancer treatments has resulted in an increased need for new clinical techniques. Standard two-dimensional (2D) models used to validate drug efficacy and screening have a low - translation potential. Recreating the tumor microenvironment at the three-dimensional (3D) level is essential to resolve these limitations in the 2D culture and improve therapy results.