Retrospective observational study shows accelerometers can monitor effects of canine pruritus treatment.

Objective: To evaluate the use of collar-mounted accelerometers to objectively monitor treatment outcomes in canine pruritus.

Methods: Observational data from 1,803 dogs from 2019 through 2023 were retrospectively analyzed to evaluate the efficacy of collar-mounted accelerometers to assess treatment efficacy for pruritic canine skin diseases. Accelerometer measurements were joined to electronic health records to establish symptoms, diagnoses, and interventions.

UK Foot and Ankle Thromboembolism (UK-FATE).

Aims: Venous thromboembolism (VTE) is a potential complication of foot and ankle surgery. There is a lack of agreement on contributing risk factors and chemical prophylaxis requirements. The primary outcome of this study was to analyze the 90-day incidence of symptomatic VTE and VTE-related mortality in patients undergoing foot and ankle surgery and Achilles tendon (TA) rupture.

Experiences of discrimination and snacking behavior in Black and Latinx children.

Little is known about how discrimination contributes to health behaviors in childhood. We examined the association between children's exposure to discrimination and their snacking behavior in a sample of youth of color (N = 164, M = 11.5 years, 49% female, 60% Black, 40% Hispanic/Latinx).

Cartiva interpositional arthroplasty versus arthrodesis in the treatment of Hallux rigidus: A retrospective comparative study with mean 2 year follow up.

Background: Hallux rigidus is a common condition characterised by first metatarsophalangeal joint (MTPJ) degeneration, pain and limited range of motion (ROM). The gold standard surgical treatment is arthrodesis, providing good pain relief, but sacrifices ROM. The Cartiva synthetic cartilage implant (SCI) has been utilised as an interpositional arthroplasty, aiming to reduce pain whilst preserving range of motion.

Changes in depressive symptoms and antibody production following influenza vaccination in adolescents and adults.

Objective: Psychological distress has been associated with dampened antibody production following vaccination. Questions remain, however, about whether psychological distress influences vaccine response uniformly across the lifespan, and whether changes in distress result in changes in antibody production across the same period.

Methods: Participants (N = 148; M = 32.

The influence of classroom context on AAC device use for nonspeaking school-aged autistic children.

: Language learning, including on a speech-generating device (SGD), relies on having communication opportunities to use language. Yet, children who use SGDs do not consistently use their devices throughout the day. As a first step towards increasing device use, it is important to determine how the numerous contexts (e.

Socioeconomic disadvantage and high-effort coping in childhood: evidence of skin-deep resilience.

Background: Low socioeconomic status (SES) is a risk factor for poor outcomes across development. Recent evidence suggests that, although psychosocial resilience among youth living in low-SES households is common, such expressions of resilience may not extend to physical health. Questions remain about when these diverging mental and physical health trajectories emerge.

Copy number alteration is an independent prognostic biomarker in triple-negative breast cancer patients.

Background: Next-generation sequencing (NGS) has enabled comprehensive genomic profiling to identify gene alterations that play important roles in cancer biology. However, the clinical significance of these genomic alterations in triple-negative breast cancer (TNBC) patients has not yet been fully elucidated. The aim of this study was to clarify the clinical significance of genomic profiling data, including copy number alterations (CNA) and tumor mutation burden (TMB), in TNBC patients.

Transcriptome-wide association analyses identify an association between ARL14EP and polycystic ovary syndrome.

Polycystic ovary syndrome (PCOS) is a common endocrine disorder, which is accompanied by a variety of comorbidities including metabolic, reproductive, and psychiatric disorders. Genome-wide association studies have identified several genetic variants that are associated with PCOS. However, these variants often occur outside of coding regions and require further investigation to understand their contribution to PCOS.

A phase 2a, randomized, double-blind, placebo-controlled, three-arm, parallel-group study to assess the efficacy, safety, tolerability and pharmacodynamics of PF-06835919 in patients with non-alcoholic fatty liver disease and type 2 diabetes.

Aim: To assess the safety, tolerability and pharmacodynamics (PD) of the ketohexokinase inhibitor PF-06835919 in participants with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D).

Materials And Methods: This double-blind, placebo-controlled, parallel-group study enrolled adults with NAFLD (≥ 8% whole liver fat [WLF] using MRI proton density fat fraction [MRI-PDFF]) and T2D on stable doses of metformin (≥ 500 mg/day). Participants received once-daily placebo, PF-06835919 150 or 300 mg for 16 weeks.

Tolerability of mycophenolate mofetil in elderly kidney transplant recipients: A retrospective cohort study.

Background: Optimal immunosuppression in elderly kidney transplant recipients (KTRs) is not well defined, with mycophenolate mofetil (MMF) being poorly tolerated. Study aim was to compare MMF dose reduction incidence and reason(s) in elderly vs. nonelderly KTRs in the 1st year after transplant with a protocol dose of 1 g/day.

Systematic Physical Assistance During Intervention for People Who Use High-Tech Augmentative and Alternative Communication Systems: The Importance of Using a Common Vocabulary.

Purpose: Speech-language pathologists (SLPs) use prompting hierarchies to facilitate learning and monitor treatment progress. When working with people who use augmentative and alternative communication (AAC), SLPs typically use physical assistance to prompt motor learning. However, there is currently no standardization regarding the number of physical prompting levels or an operational definition for each prompting level.

Emotional Distress, Targeted Rejection, and Antibody Production After Influenza Vaccination in Adolescence.

Objective: The purpose of this study was to explore how both ongoing emotional distress and the experience of a targeted rejection over the past 6 months are associated with adolescents' antibody response to influenza virus vaccination. We predicted that experiencing a targeted rejection would amplify the hypothesized negative association between emotional distress and antibody response after vaccination.

Methods: Adolescent participants (N = 148) completed two study visits (mean [standard deviation] days between visits = 27.

A Systematic Review and Analysis of the Use of Polygenic Scores in Pharmacogenomics.

Polygenic scores (PGSs) have emerged as promising tools for complex trait risk prediction. The application of these scores to pharmacogenomics provides new opportunities to improve the prediction of treatment outcomes. To gain insight into this area of research, we conducted a systematic review and accompanying analysis.

Within arm's reach: The role of proximity in speech generating device use of ambulatory children with autism.

Augmentative and Alternative Communication (AAC) provides an alternative means of communication for individuals who are unable to effectively communicate using spoken language. The present study seeks to investigate the role of proximity in facilitating AAC (specifically Speech Generating Devices; SGD) use in a homogeneous population: ambulatory school-aged children with autism spectrum disorder (ASD). Twelve school-age children with ASD who use an SGD as their primary mode of communication participated in the study.

Recalled Neighborhood Environments, Parental Control, and Cytokine-Mediated Response to Viral Challenge.

Objective: Neighborhood risk in childhood is associated with poor health across the life span. However, many people who are reared in risky neighborhoods remain healthy in adulthood. In the context of high-risk neighborhoods, parenting practices that are controlling might promote better physical health outcomes later in life.

Posture-Dependent Variability in Wrist Ballistocardiogram-Photoplethysmogram Pulse Transit Time: Implication to Cuff-Less Blood Pressure Tracking.

Objective: Toward the ultimate goal of robust cuff-less blood pressure (BP) tracking with wrist wearables against postural changes, the goal of this work was to investigate posture-dependent variability in pulse transit time (PTT) measured with ballistocardiogram (BCG) and photoplethysmogram (PPG) signal pair at the wrist.

Methods: BCG and PPG signals were acquired from 25 subjects under the combination of 3 body (standing, sitting, and supine) and 3 arm (vertical in head-to-foot direction, placed on the chest, and holding a shoulder) postures. PTT was computed as the time interval between the BCG J wave and the PPG foot, and the impact of the 9 postures on PTT was analyzed by invoking an array of possible physical mechanisms.

Deep Learning Classification of Canine Behavior Using a Single Collar-Mounted Accelerometer: Real-World Validation.

Collar-mounted canine activity monitors can use accelerometer data to estimate dog activity levels, step counts, and distance traveled. With recent advances in machine learning and embedded computing, much more nuanced and accurate behavior classification has become possible, giving these affordable consumer devices the potential to improve the efficiency and effectiveness of pet healthcare. Here, we describe a novel deep learning algorithm that classifies dog behavior at sub-second resolution using commercial pet activity monitors.

Staples and locking plates provide comparable outcomes for fixation of first metatarsal dorsiflexion osteotomies in pes cavovarus.

Background: One commonly encountered deformity within the cavovarus foot is plantarflexion of the first metatarsal which may be a primary or secondary deformity. Correcting the plantarflexion may be achieved through a dorsiflexion osteotomy although the optimal fixation device for this osteotomy has not been determined. This clinical study compared the outcomes using staples and locking plates.

Evidence for anti-inflammatory effects of firocoxib administered to mares with experimentally induced placentitis.

Problem: Minimal evidence exists supporting therapeutic selections for equine placentitis. The goal of this study was to characterize the anti-inflammatory effects of firocoxib when administered to mares with placentitis.

Methods: Mares (gestation D270-300) were assigned to: INFECT (n = 6; placentitis, no treatment), FIRO (n = 6; placentitis, firocoxib, 0.

Dysregulated Host Responses Underlie 2009 Pandemic Influenza-Methicillin Resistant Coinfection Pathogenesis at the Alveolar-Capillary Barrier.

Influenza viruses are a continual public health concern resulting in 3-5 million severe infections annually despite intense vaccination campaigns and messaging. Secondary bacterial infections, including , result in increased morbidity and mortality during seasonal epidemics and pandemics. While coinfections can result in deleterious pathologic consequences, including alveolar-capillary barrier disruption, the underlying mechanisms are poorly understood.

Metabolomic Profile of Allantoic and Amniotic Fluid in Late-term Gestational Mares Characterized by H-nuclear Magnetic Resonance Spectroscopy.

The amniotic and allantoic fluid compartments in the mare serve essential roles throughout pregnancy and parturition. Although the global metabolomic profile of amniotic fluid in women has been extensively characterized, current data for equine fetal fluids are limited. Therefore, the goal of this study was to characterize the global metabolomic profile of equine allantoic and amniotic fluid through nuclear magnetic resonance spectroscopy.