Publications by authors named "Lyimo Dafrossa"

Article Synopsis
  • Evaluating vaccine-related research is essential for optimizing vaccination programs, with an emphasis on understanding their performance, impact, and economic value.
  • The WHO's IVIR-AC meets bi-annually to review and discuss relevant research, with the latest meeting held from September 11-13, 2023, covering eight diverse topics.
  • Topics included measles immunization strategies, dengue vaccine risk-benefit analysis, COVID-19 modeling in Africa, and the Immunization Agenda 2030, all aimed at improving vaccine impact and policy.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates Rotavirus genotypes in Tanzania from 2013 to 2018, specifically after the introduction of the ROTARIX vaccine.
  • A significant decline in Rotavirus positivity rates was noted, dropping from 29.3% to 17.8% over the study period, indicating the vaccine's effectiveness.
  • The analysis revealed changes in circulating genotypes, with the G1P[8] strain decreasing significantly while the G9P[4] strain surged, which underscores the need for ongoing surveillance of Rotavirus strains post-vaccination.
View Article and Find Full Text PDF

Rubella virus (RV) infection in susceptible women during the first trimester of pregnancy is associated with congenital Rubella syndrome (CRS). In countries where a vaccination program is implemented, active case surveillance is emphasized. This report documents the magnitude of active cases before and after vaccine implementation in Tanzania.

View Article and Find Full Text PDF

Globally, measles remains a major cause of child mortality, and rubella is the leading cause of birth defects among all infectious diseases. In 2012, the World Health Assembly endorsed the Global Vaccine Action Plan that set a target to eliminate Measles-Rubella (MR) in five of the six World Health Organization (WHO) regions by 2020. This was cross-sectional study employed both quantitative and qualitative research methods.

View Article and Find Full Text PDF

Background: In April 2018, Tanzania introduced the human papillomavirus (HPV) vaccine nationally to 14-year-old girls, utilizing routine delivery strategies (i.e. vaccinating girls at health facilities and community outreach, including schools).

View Article and Find Full Text PDF

Background: Cervical cancer is the leading cause of cancer among women in Tanzania, with approximately 10,000 new cases and 7,000 deaths annually. In April 2018, the Government of Tanzania introduced 2 doses of human papillomavirus (HPV) vaccine nationally to adolescent girls to prevent cervical cancer, following a successful 2-year pilot introduction of the vaccine in the Kilimanjaro Region.

Methods: We interviewed key informants at the national level in Tanzania from February to November 2019, using a semi-structured tool to better understand national decision-making and program implementation.

View Article and Find Full Text PDF

Background: To achieve Measles and Rubella elimination and Polio Endgame goals, Tanzania implemented country-wide integrated Supplementary Immunization Activities (SIAs) in October 2019 involving two injectable vaccines of MR and IPV. The SIAs targeted children aged between 9 and 59 months for Measles-Rubella and 18 to 42 months for IPV vaccines. This article aims to share lessons learnt in the implementation of SIAs field guidelines in Tanzania in 2019 to inform future implementation of the SIAs within and outside the country's boundaries.

View Article and Find Full Text PDF

Introduction: Information on the costs of routine immunization programs is needed for budgeting, planning, and domestic resource mobilization. This information is particularly important for countries such as Tanzania that are preparing to transition out of support from Gavi, the Vaccine Alliance. This study aimed to estimate the total and unit costs for of child immunization in Tanzania from July 2016 to June 2017 and make this evidence available to key stakeholders.

View Article and Find Full Text PDF

Background: As more countries transition from paper-based to electronic immunization registries (EIRs) to collect and track individual immunization data, guidance is needed for successful adoption and use of these systems. Little research is available on the determinants of EIR use soon after introduction. This observational study assesses the determinants of facility health care workers' use of new EIRs in Tanzania and Zambia, implemented during 2016 to 2018.

View Article and Find Full Text PDF
Article Synopsis
  • The monovalent rotavirus vaccine (RV1) was introduced in Tanzania in January 2013, targeting infants at 6 and 10 weeks of age as part of the Reach Every Child initiative, with a focus on monitoring its effectiveness through a sentinel surveillance system.
  • Pre-vaccine data showed high rotavirus positivity rates at Tanga Hospital (41%) and Bugando Medical Centre (58%), which significantly dropped to 14% and 18% respectively after the vaccine was introduced, demonstrating a notable decrease in infections.
  • The vaccine showed an effectiveness of 53% against hospitalizations for rotavirus among children aged 5-23 months and 66% against those requiring intravenous rehydration, while post-vaccine trends
View Article and Find Full Text PDF

A National Immunization Program Review (NIP Review) is a comprehensive external assessment of the performance of a country's immunization programme. The number of recommended special-topic NIP assessments, such as those for vaccine introduction or vaccine management, has increased. These assessments often have substantial overlap with NIP reviews, raising concern about duplication.

View Article and Find Full Text PDF

Global health practitioners are increasingly advocating for the integration of community-based health-care platforms as a strategy for increasing the coverage of programs, encouraging program efficiency, and promoting universal health-care goals. To leverage the strengths of compatible programs and avoid geographic and temporal duplications in efforts, the Tanzanian Ministry of Health and Social Welfare coordinated immunization and neglected tropical disease programs for the first time in 2014. Specifically, a measles and rubella supplementary vaccine campaign, mass drug administration (MDA) of ivermectin and albendazole, and Vitamin A were provisionally integrated into a shared community-based delivery platform.

View Article and Find Full Text PDF

Having data on the costs of the immunization system can provide decision-makers with information to benchmark the costs when evaluating the impact of new technologies or programmatic innovations. This paper estimated the supply chain and immunization service delivery costs and cost per dose in selected districts in Kenya and Tanzania. We also present operational data describing the supply chain and service delivery points (SDPs).

View Article and Find Full Text PDF

Background: In 2009, a project was implemented in 8 primary health clinics throughout Tanzania to explore the feasibility of integrating pediatric HIV prevention services with routine infant immunization visits.

Methods: We conducted interviews with 64 conveniently sampled mothers of infants who had received integrated HIV and immunization services and 16 providers who delivered the integrated services to qualitatively identify benefits and challenges of the intervention midway through project implementation.

Findings: Mothers' perceived benefits of the integrated services included time savings, opportunity to learn their child's HIV status and receive HIV treatment, if necessary.

View Article and Find Full Text PDF

Background: Without treatment, approximately half of HIV-infected infants die by age 2 years, and 80% die before age 5 years. Early identification of HIV-infected and HIV-exposed infants provides opportunities for life-saving interventions. We evaluated integration of HIV-related services with routine infant immunization in Tanzania.

View Article and Find Full Text PDF