Action of the natural compound gomisin a on Ca movement in human prostate cancer cells.

Gomisin A is a dietary lignan compound isolated from the fruit of Schisandra chinensis and has many pharmacological properties, including hepato-protective, anti-diabetic, and anti-oxidative activities. However, the benefit of gomisin A is still not well understood. The action of gomisin A is diverse.

Hydroxytyrosol [2-(3,4-dihydroxyphenyl)-ethanol], a natural phenolic compound found in the olive, alters Ca signaling and viability in human HepG2 hepatoma cells.

Hepatotoma is the leading type of primary liver cancer in adults and third cause of death in the world. Hydroxytyrosol is a natural phenol existing in olive (Olea europaea L.).

Exploration of thioridazine-induced Ca signaling and non-Ca-triggered cell death in HepG2 human hepatocellular carcinoma cells.

Thioridazine, belonging to first-generation antipsychotic drugs, is a prescription used to treat schizophrenia. However, the effect of thioridazine on intracellular Ca concentration ([Ca]) and viability in human liver cancer cells is unclear. This study examined whether thioridazine altered Ca signaling and viability in HepG2 human hepatocellular carcinoma cells.

Investigation of effect of tectorigenin (O-methylated isoflavone) on Ca signal transduction and cytotoxic responses in canine renal tubular cells.

Tectorigenin, a traditional Chinese medicine, is isolated from the flower of plants such as Pueraria thomsonii Benth. It is an O-methylated isoflavone, a type of flavonoid. Previous studies have shown that tectorigenin evoked various physiological responses in different models, but the effect of tectorigenin on cytosolic-free Ca levels ([Ca]) and cytotoxicity in renal tubular cells is unknown.

Action of chlorzoxazone on Camovement and viability in human oral cancer cells.

Chlorzoxazone is a skeletal muscle relaxant. However, the effect of chlorzoxazone on intracellular Ca concentrations ([Ca]) in oral cancer cells is unclear. This study examined whether chlorzoxazone altered Ca signaling and cell viability in OC2 human oral cancer cells.

The exploration of effect of terfenadine on Ca signaling in renal tubular cells.

Terfenadine, an antihistamine used for the treatment of allergic conditions, affected Ca-related physiological responses in various models. However, the effect of terfenadine on cytosolic free Ca levels ([Ca]) and its related physiology in renal tubular cells is unknown. This study examined whether terfenadine altered Ca signaling and caused cytotoxicity in Madin-Darby canine kidney (MDCK) renal tubular cells.

Exploration of Niflumic Acid’s Action on Ca²⁺ Movement and Cell Viability in Human Osteosarcoma Cells.

Niflumic acid, a drug used for joint and muscular pain, affected Ca²⁺ signaling in different models. However, the effect of niflumic acid on Ca²⁺ homeostasis and Ca²⁺-related physiology in human osteosarcoma cells is unknown. This study examined the effect of niflumic acid on cytosolic free Ca²⁺ concentrations ([Ca²⁺]i) in MG63 human osteosarcoma cells.

Effects of timolol on Ca handling and viability in human prostate cancer cells.

Timolol is a medication used widely to treat glaucoma. Regarding Ca signaling, timolol was shown to modulate Ca-related physiology in various cell types, however, the effect of timolol on Ca homeostasis and cell viability has not been explored in human prostate cancer cells. The aim of this study was to explore the effect of timolol on intracellular Ca concentrations ([Ca]) and viability in PC3 human prostate cancer cells.

Effect of Captopril on Ca²⁺ Homeostasis and Cell Viability in Human Hepatoma Cells.

Captopril, an angiotensin-converting enzyme (ACE) inhibitor, induced different Ca²⁺ signaling responses in various cell models. However, the effect of captopril on Ca²⁺ homeostasis and cell viability in hepatoma cells is unknown. This study examined whether captopril altered Ca²⁺ homeostasis and viability in HepG2 human hepatoma cells.

The effect of magnolol on Ca homeostasis and its related physiology in human oral cancer cells.

Objective: Magnolol, a polyphenol compound from herbal medicines, was shown to alter physiology in various cell models. However, the effect of magnolol on Ca homeostasis and its related physiology in oral cancer cells is unclear. This study examined whether magnolol altered Ca signaling and cell viability in OC2 human oral cancer cells.

Midazolam induces apoptosis in MA-10 mouse Leydig tumor cells through caspase activation and the involvement of MAPK signaling pathway.

Purpose: The present study aims to investigate how midazolam, a sedative drug for clinical use with cytotoxicity on neuronal and peripheral tissues, induced apoptosis in MA-10 mouse Leydig tumor cells.

Methods: The apoptotic effect and underlying mechanism of midazolam to MA-10 cells were investigated by flow cytometry assay and Western blotting methods.

Results: Data showed that midazolam induced the accumulation of the MA-10 cell population in the sub-G1 phase and a reduction in the G2/M phase in a time- and dose-dependent manner, suggesting an apoptotic phenomenon.

Factors associated with sex hormones and erectile dysfunction in male Taiwanese participants with obesity.

Introduction: Obesity has been receiving an increasing amount of attention recently, but investigations regarding the potential impact of obesity, sexual behaviors, and sex hormones on erectile dysfunction (ED) in men have not completely clarified the association.

Aim: To identify the relationship between ED, sexual behavior, sexual satisfaction, sex hormones, and obesity in older adult males in Taiwan.

Methods: Data were obtained from a baseline survey of 476 older adult males (≧40 years old).

Apoptotic effect of cisplatin and cordycepin on OC3 human oral cancer cells.

Objective: To evaluate apoptotic effects of cisplatin and cordycepin as single agent or in combination with cytotoxicity in oral cancer cells.

Methods: The influences of cisplatin (2.5 μg/mL) and/or cordycepin treatment (10 or 100 μmol/L) to human OC3 oral cancer cell line were investigated by morphological observation for cell death appearance, methylthiazoletetrazolium (MTT) assay for cell viability, flow cytometry assay for cell apoptosis, and Western blotting for apoptotic protein expressions.

Metabolic outcome for diabetes shared care program outpatients in a veterans hospital of southern Taiwan.

Background: To evaluate the metabolic outcomes of the Diabetes Shared Care Program (DSCP) for Type 2 diabetes after completion of 1 year and 3 years of intervention.

Methods: Total 162 Type 2 diabetes (average age 67.14 years with 62.