Leishmanicidal activity and cytotoxicity of compounds from two Annonacea species cultivated in Northeastern Brazil.

Introduction: Visceral leishmaniasis is endemic in 88 countries, with a total of 12 million people infected and 350 million at risk. In the search for new leishmanicidal agents, alkaloids and acetogenins isolated from leaves of Annona squamosa and seeds of Annona muricata were tested against promastigote and amastigote forms of Leishmania chagasi.

Methods: Methanol-water (80:20) extracts of A.

Phenolic content and antioxidant and antiacetylcholinesterase properties of honeys from different floral origins.

Twenty-three honey samples of Apis mellifera L. forged on plants from northeastern Brazil were analyzed to determine total phenolic content, flavonoid content, antioxidant activity, and antiacetylcholinesterase activity. The total phenol content was determined by using the Folin-Ciocalteu method, and the flavonoid content was analyzed using by the aluminum chloride method.

Effects of Myracrodruon urundeuva extracts on egg hatching and larval exsheathment of Haemonchus contortus.

The anthelmintic resistance has limited the control of gastrointestinal nematodes of small ruminants and thus has awakened interest in the study of tanniferous plants as a source of anthelmintics. These experiments were carried out to evaluate the in vitro efficacy of Myracrodruon urundeuva leaf extract (LE) and stem extract (SE) against Haemonchus contortus. An inhibitor of tannins, polyvinyl polypyrrolidone (PVPP), was used to verify if these metabolites are involved in the anthelmintic activity of the extracts.