Publications by authors named "Lydia Yao"
Importance: Nicotinamide metabolites have recently been implicated in increased risk of major cardiovascular events (MACE). Supportive data about clinical risk of MACE for nicotinamide users is lacking.
Objective: To determine whether nicotinamide use results in an increase of MACE.
Importance: Many patients will develop more than one skin cancer, however most research to date has examined only case status.
Objective: Describe the frequency and timing of the treatment of multiple skin cancers in individual patients over time.
Design: Longitudinal claims and electronic health record-based cohort study.
Immune checkpoint inhibitor-mediated colitis (IMC) is a common adverse event of treatment with immune checkpoint inhibitors (ICI). We hypothesize that genetic susceptibility to Crohn's disease (CD) and ulcerative colitis (UC) predisposes to IMC. In this study, we first develop a polygenic risk scores for CD (PRS) and UC (PRS) in cancer-free individuals and then test these PRSs on IMC in a cohort of 1316 patients with ICI-treated non-small cell lung cancer and perform a replication in 873 ICI-treated pan-cancer patients.
View Article and Find Full Text PDFIncentivised by breakthroughs and data generated by the high-throughput sequencing technology, this paper proposes a distance-based framework to fulfil the emerging needs in elucidating insights from the high-dimensional microbiome data in psychiatric studies. By shifting focus from traditional methods that focus on the observations from each subject to the between-subject attributes that aggregate two or more subjects' entire feature vectors, the described approach revolutionises the conventional prescription for high-dimensional observations via microbiome diversity. To this end, we enrich the classical generalised linear models to articulate the multivariable regression relationship between distance-based variables.
View Article and Find Full Text PDFArticle Synopsis
- Immune checkpoint inhibitors (ICIs) have vastly improved cancer treatment but can lead to serious immune-related adverse events (irAEs), particularly immune checkpoint inhibitor-mediated colitis (IMC), which can mimic diseases like Crohn's and ulcerative colitis.
- Researchers hypothesized that genetic predispositions related to these diseases might increase the risk of developing IMC in cancer patients receiving ICIs, and they developed polygenic risk scores (PRS) to test this in a study of 1,316 non-small cell lung cancer patients.
- The study found that higher PRS scores were linked to an increased risk of all-grade and severe IMC, suggesting that genetic testing could help identify patients at higher risk and enable better monitoring and
Motivation: Making sense of networked multivariate association patterns is vitally important to many areas of high-dimensional analysis. Unfortunately, as the data-space dimensions grow, the number of association pairs increases in O(n2); this means that traditional visualizations such as heatmaps quickly become too complicated to parse effectively.
Results: Here, we present associationSubgraphs: a new interactive visualization method to quickly and intuitively explore high-dimensional association datasets using network percolation and clustering.