Addressing the gaps in homeostatic mechanisms of copper and copper dithiocarbamate complexes in cancer therapy: a shift from classical platinum-drug mechanisms.

The platinum drug, cisplatin, is considered as among the most successful medications in cancer treatment. However, due to its inherent toxicity and resistance limitations, research into other metal-based non-platinum anticancer medications with diverse mechanisms of action remains an active field. In this regard, copper complexes feature among non-platinum compounds which have shown promising potential as effective anticancer drugs.

Beyond DNA-targeting in Cancer Chemotherapy. Emerging Frontiers - A Review.

Modern anti-cancer drugs target DNA specifically for rapid division of malignant cells. One downside of this approach is that they also target other rapidly dividing healthy cells, such as those involved in hair growth leading to serious toxic side effects and hair loss. Therefore, it would be better to develop novel agents that address cellular signaling mechanisms unique to cancerous cells, and new research is now focussing on such approaches.

Synthesis, characterisation and ion-binding properties of oxathiacrown ethers appended to [Ru(bpy)]. Selectivity towards Hg, Cd and Pb.

A series of complexes with oxathiacrown ethers appended to a [Ru(bpy)] moiety have been synthesized and characterised using H NMR, C NMR, IR, electronic absorption and emission spectroscopies, mass spectrometry and elemental analyses. The complexes exhibit strong MLCT luminescence bands in the range 608-611 nm and one reversible metal centred oxidation potential in the range 1.00-1.