Publications by authors named "Lydia R Gushgari"
An automated proteomic platform for producing and screening an array of functional proteins on biosensor surfaces was developed to address the challenges of measuring proteomic interaction kinetics in high throughput (HTP). This technology is termed Sensor-Integrated Proteome On Chip (SPOC) which involves cell-free protein expression in nano-liter volume wells (nanowells) directly from rapidly customizable arrays of plasmid DNA, facilitating simultaneous capture-purification of up to 2400 unique full-length folded proteins onto a 1.5 sq-cm surface of a single gold biosensor chip.
View Article and Find Full Text PDFArticle Synopsis
- Environmental factors like infections, chemicals, and diet significantly influence autoimmune diseases, but the impact of food components is often overlooked.
- The oral tolerance mechanism is crucial for managing immune reactions to food; when it fails, it can lead to immune responses against dietary antigens that resemble body tissues, potentially worsening autoimmune conditions.
- Research suggests that certain food proteins, especially when modified by toxins, might trigger autoimmune reactions, while other foods could promote immune stability and encourage gut health, highlighting the need for further studies on diet's role in preventing autoimmune diseases.