Aspergilloma in a hydatid cavity.

Fungal colonization by aspergillus usually occurs in pre-existing lung cavities mostly due to post-tubercular sequelae. Colonization of a hydatid cavity is very rare. We hereby report this unusual co-infection in a 55 years old diabetic male patient who was diagnosed pre-operatively and was managed with surgery, anti-fungal agents, and anthelminthics.

Expected plazomicin susceptibility in India based on the prevailing aminoglycoside resistance mechanisms in Gram-negative organisms derived from whole-genome sequencing.

Background: Aminoglycoside resistance is a growing challenge, and it is commonly mediated by the aminoglycoside-modifying enzymes (AMEs), followed by 16S rRNA methyl transferase. Plazomicin, a novel aminoglycoside agent approved by the Food and Drug Administration for complicated urinary tract infections is proven to overcome resistance mediated by AMEs but not due to 16S rRNA methyl transferase (16SRMTases). We undertook this study to predict the efficacy of plazomicin in India based on the antimicrobial resistance profile derived from whole-genome sequencing (WGS).

Umbilical Diphtheria: Resurgence of a Forgotten Entity.

Diphtheria has had a resurgence in India over the past decade. We present a case of umbilical diphtheria in a neonate, who had a good outcome with administration of anti-toxin and antibiotics.

A Distinct Geographic Variant of sasX in Methicillin-Resistant Staphylococcus aureus ST239 and ST368 Lineage from South India.

Staphylococcal surface protein sasX is a colonization mediating virulence factor in ST239 methicillin-resistant Staphylococcus aureus (MRSA) strains, which potentially contribute to its successful establishment. We aimed to study the presence and dissemination of sasX in clinical MRSA isolates and among MRSA carriers. A total of 450 nonduplicate clinical MRSA isolates recovered from blood cultures between 2013 and 2017 were included in this study.