Hydrogel Cross-Linking via Thiol-Reactive Pyridazinediones.

Thiol-reactive Michael acceptors are commonly used for the formation of chemically cross-linked hydrogels. In this paper, we address the drawbacks of many Michael acceptors by introducing pyridazinediones as new cross-linking agents. Through the use of pyridazinediones and their mono- or dibrominated analogues, we show that the mechanical strength, swelling ratio, and rate of gelation can all be controlled in a pH-sensitive manner.

Selectivity and stability of N-terminal targeting protein modification chemistries.

Protein N-termini provide uniquely reactive motifs for single site protein modification. Though a number of reactions have been developed to target this site, the selectivity, generality, and stability of the conjugates formed has not been studied. We have therefore undertaken a comprehensive comparative study of the most promising methods for N-terminal protein modification, and find that there is no 'one size fits all' approach, necessitating reagent screening for a particular protein or application.

Catalytic enantioselective synthesis of 1,4-dihydropyridines the addition of C(1)-ammonium enolates to pyridinium salts.

The regio- and stereoselective addition of C(1)-ammonium enolates - generated from aryl esters and the isothiourea catalyst ()-BTM - to pyridinium salts bearing an electron withdrawing substituent in the 3-position allows the synthesis of a range of enantioenriched 1,4-dihydropyridines. This represents the first organocatalytic approach to pyridine dearomatisation using pronucleophiles at the carboxylic acid oxidation level. Optimisation studies revealed a significant solvent dependency upon product enantioselectivity, with only toluene providing significant asymmetric induction.

Entry-Level Master's Programs in Nursing: Review of Programmatic Features.

Background: This review describes the programmatic features of entry-level master's programs in nursing in the United States that result in a generalist degree for individuals with a baccalaureate degree in another field. The number of entry-level Master of Science in Nursing programs has grown over the past decade, increasing the importance of understanding the features, similarities, and differences among these programs.

Method: Using a custom report of accredited schools of nursing with entry-level master's programs from the American Association of Colleges of Nursing and the Accreditation Commission for Education in Nursing's website, we conducted a program review to describe the programs' features.