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Publications by authors named "Lydia A Salomatina"

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Aminodihydrophthalazinedione Sodium Transdermal Therapeutic System Specific Activity on an ExperimentalModel of Extensive Liver Resection.
Eugenia G Kuznetsova Lydia A Salomatina Olga M Kuryleva Lyudmila A Kirsanova Zalina Z Gonikova

Life (Basel)

February 2023

Article Synopsis
  • The authors found that the transdermal therapeutic system (TTS) for the immunomodulator ADPS provides similar drug absorption as intramuscular injections, but with lower peak blood levels and extended duration in the body.
  • The study aimed to explore whether this transdermal method could enhance liver regeneration after extensive liver resection (ELR).
  • Results showed that 48 hours after ELR, the ADPS TTS significantly increased liver cell activity and improved recovery rates in rats compared to the control group by 72 hours post-surgery.
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