[Iron deficiency syndromes and their correction with nutritional support in elderly patients with colo-rectal cancer.].

51 patients with operated colorectal cancer T1N0M0, T3N1M0 and T4N0M1 at the age of 67±2,3 years receiving adjuvant chemotherapy and nutritional support (NS) were examined. Nutritional status was assessed using alimentazione-volume diagnosis to the points on L.N.

[SEROTONERGIC REGULATION OF IMMUNITY. PART I].

The review describes the influence of serotonin (5-HT) and its receptor, transporter SERT and nuclear factor Nf-kB on the immune function of the body, particularly in the digestive tract. The mechanisms of the synthesis, metabolism and catab. olism of 5-HT are characterized.

[NERVOUS REGULATION OF BILIARY TRACT MOTILITY].

Aim: The study of mechanisms of regulation of biliary tract motility by divisions of autonomic nervous system (ANS).

Material And Methods: Experiments were carried out on rabbits, chinchillas weighing 3.5-4 kg using gentle methods of treatment of experimental animals.

THE ROLE OF BILE ACIDS IN THE REGULATION OF LIPID AND CARBOHYDRATE METABOLISM IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE AND DIABETES TYPE2.

Bile acids regulate glucose and lipid metabolism. Aim -determination of total serum bile acids in patients with NAFLD and in combination with type 2 diabetes. To determine the inflammatory markers (nitric oxide, endotoxin, phospholipase A2, malondialdehyde) effects role for the synthesis and transport of bile acids.

[Serotonergic regulation of the immune system].

The paper presents evidence on the important contribution of the peripheral serotonin system in the process of immunomodulation. The main components of the system - serotonin, receptors and serotonin transporter - are described. Possible mechanisms of serotonin regulation of activity of immune cells - lymphocytes, macrophages and dendritic cells - are reviewed.

[SEROTONERGIC REGULATION OF THE DUODENUM CONTRACTIONS].

The review contains an analysis of literature data on enhancement mechanisms of duodenum contractions arising during stimulation of the sympathetic trunk in the right thoracic cavity in dogs. It is established in experiments that There are mostly enhancement, not relaxation of the organ contraction occured. In this case the stimulatory effect due to the excitation of the parasympathetic fibers is excluded.

[THE DIGESTIVE TRACT MOTILITY AND NUTRITIONAL SUPPORT WITH POSTGASTRORESECTIONAL SYNDROME].

The variety of clinical manifestations operated stomach fits in the sequence of pathological syndromes: dumping and hypoglycemic syndromes, postgastroresectional post gastrectomy anemia, afferent loop syndrome, postoperative dystrophy, reflux esophagitis, a syndrome of "small" stomach, and hypoglycemic syndrome. Aim--to elucidate the role of disorders of motor function of the gastrointestinal tract in postgastroresectional syndromes and their correction. The nutrient administration reduced a motor function level of the stomach, restore motor function of the duodenum and ascending colon intestine, normalize ino- and chronotropic relations in the smooth muscles of the sigmoid colon.

[THE MOTILITY OF THE COLON WITH THE CONTRACTILE ACTIVITY OF THE GALLBLADDER IN PATIENTS WITH EXTENSIVE RESECTION OF THE COLON AND ENTERAL NUTRITIONAL SUPPORT].

The aim of investigation--to study the motor function of the colon and gall bladder after hemicolectomy. Electromyog- raphy is the method to study motility of gastrointestinal tract. This method allow to assess the condition of the motor func- tions of the various parts of the intestine, and also to compare, in particular, the motility of the colon with the contractile activity of the gallbladder in patients with extensive resection of the colon (the right- or left-sided hemicolectomy).

Serotonin regulates contractile activity of the uterus in non-pregnant rabbits.

Serotonin (5-HT) can stimulate the cholinergic system of the uterus by indirect actions on the modulation of reflexes and a direct action on smooth muscles. We investigated the role of 5-HT in the regulation of the cholinergic activity in the uterine parts of non-pregnant rabbits. The right vagus or pelvic nerve and the left sympathetic trunk were stimulated by an electrical field, and the uterine contractile activity was evaluated by measuring the amplitude and frequency of slow wave electromyogram (EMG), with the surface of microelectrodes applied to the uterus bottom, body, and cervix, respectively.

Pacemakers of the upper divisions of the digestive tract.

Pacemaker cells of the upper portion of the digestive tract were studied by electromyography of various parts of the stomach and duodenum. Pacemaker cells of the stomach were located mainly at the interface between the lesser curvature and cardia and in the proximal part of the antrum and were characterized by high spontaneous slow-wave and spike activities. Antroduodenal coordination contributes to sequential motor activity of the stomach and duodenum.

Pacemakers in extrahepatic biliary ducts.

Pacemaker cells in the biliary system were studied by using electromyographic and histological methods. The pacemaker cells of the duodenal-biliary complex are located in the bile duct (predominantly, in its proximal part). They are characterized with enhanced spontaneous spike and slow-wave electrical activity.

[Lymphocyte apoptosis enhancement by the synthetic peptide E in experimental ulcer].

The influence of regulatory peptide type of AFP on the course of experimental ulcer was investigated. It has been shown that activation of apoptosis enhances local necrotic inflammatory reaction, on the one hand, and enables the development of adhesions with on the other.

[Gastroprotective effect of honey and bee pollen].

The effect of honey and pollen for an experimental gastric ulcer in rats by electromyography was investigated Okabe ulcer by applying the 100% acetic acid in the gastric serosa was simulated. Honey and pollen prevent the development of painful gastric motility, which confirms its gastroprotective action.

[Lymphocyte apoptosis enhancement by the synthetic peptide of human alpha-fetoprotein (AFP 14-20) in experimental ulcer].

The influence of regulatory peptide type of AFP on the course of experimental ulcers was investigated. It has been shown that activation of apoptosis by AFP enhance local necrotic inflammatory reaction, on the one hand, and enables the development of adhesions with the other.

[Non-steroidal anti-inflammatory drugs in the correction of experimental ulcerative colitis].

Non-steroidal anti-inflammatory drugs influence the electromyogram of smooth muscle of ileum, the cecum and the ascending portion of the colon in rats during ulcerative colitis was investigated. It was shown that COX-2 inhibitors normalized the electromotor activity of ileo-ascendo complex, lowered infiltration of round cells in mucous-submucosal tissue and blood flow.

[Nervous regulation of thyroid function].

Review examines the autonomic regulation of thyroid function. Review examines the issues of autonomic regulation of the thyroid gland. Activation of the central a-adrenergic mechanisms increases the release of thyroid-stimulating hormone of pituitary mainly due to the stimulation of its secretion.

The role of mesenchymal stem cells and serotonin in the development of experimental pancreatitis.

Pancreatitis was modeled before and after preliminary transplantation of stem cells and serotonin. It was demonstrated that transplantation of mesenchymal stem cells and activation of serotoninergic system prevent the development of pancreatitis.

[Nitric oxide and autonomic nervous system].

The review of the literature on the role of nitric oxide in the regulation of cardiovascular, gastrointestinal and bronchopulmonary systems is presented. Mechanisms of interaction of nitric oxide with cholinergic and adrenergic divisions of the vegetative nervous system are described. The results of studies on the role of NO in the regulation of contractile function of the esophagus are presented.

[Serotoninergic regulation of colonic motor function].

The review deals with the serotoninergic regulation of colonic motor function. Serotonin (HT), its receptors and transporter, the enzymes of synthesis and degradation, play an important role in the regulation of colonic motor activity. Activation of 5-HT1, 5-HT2B, 5-HT3, and 5-HT4 receptors leads to increased colonic motor function.

Role of serotonin receptors in regulation of contractile activity of urinary bladder in rabbits.

Objective: To evaluate the role of different serotonin (5-hydroxytryptamine [5-HT]) receptor subtypes on urinary bladder contraction, pharmacologic analysis of electromotor activity (EMA) variation was performed using a rabbit bladder model.

Materials And Methods: Measurements of EMA were performed on 3 urinary bladder portions: top, body, and trigone. The experiments were performed on 24 Shinshilla rabbits of both sexes, 5-6 months old, and weighing 2.

[Dynamics of ultrastructural organization of liver cells in experimental peritonitis].

In the experiment on Wistar rats by methods of light and electron microscopy an ultrastructural disorders of the liver cells in various stages of peritonitis were investigated. It was shown that the reactive phase of experimental peritonitis associates with dystrophic changes of the hepatocytes and the endotheliocytes of sinusoids. These reversible changes are explained by an adaptive response of cells to inflammation.

[Serotonergic regulation of motor activity of duodenum].

Objective--find the possible role of serotonin in the regulation of motor activity of the duodenum. It is shown that the activation of ganglionic 5-HT4, 5-HT3 receptors and 5-HT1--and 5-HT2 receptors of effector cells is accompanied by changes in electromotor activity of the intestine. Blockade of these receptors to varying degrees inhibit stimulatory effect of serotonin.

[Gastroesophageal reflux disease model].

The model of gastroesophageal reflux disease by administration of 0.2-0.25 ml of a 1% solution of methylene blue to fundal division of rat stomach was created.

[Effects of radiation of decimeter range on the motor function of the gastrointestinal and biliary tracts].

Characteristics of the motor function of the upper gastrointestinal tract, small intestine and colon and biliary tract under radiation of dm range were obtained. The radiation source was a mobile phone brand Nokya. Motor function of the gastrointestinal and biliary tract was evaluated recording electromyogram (EMG) from silver electrodes imposed on the body surface in the projection point of the corresponding abdominal organs; frequency (in minutes) and amplitude (mV) and EMG spikes are measured.

[Nervous regulation of contractile function of the rectum].

Basic systems of autonomic regulation of contractile function of the rectum are presented. Activation of the parasympathetic system has a predominantly stimulatory influence on the contractile function of the rectum. Activation of alpha1-, alpha2- and beta2-adrenergic receptors of the sympathetic nervous system inhibits contractile function of the rectum, and activation of alphal-adrenergic receptors stimulates contractile function of rectum sphinkters.