[Arrhythmia in patients with chronic heart insufficiency and type 2 diabetes mellitus].

Unlabelled: The aim of the work was to study character, frequency and peculiarities of arrhythmia in patients with chronic heart insufficiency (CHI) depending on its etiology and type 2 diabetes mellitus (DM2).

Materials And Methods: In-depth clinical observation of 197 patients (mean age 61.3 +/- 0.

[Treatment of DIC syndrome in patients with severe craniocerebral trauma].

Transfusion of fresh-frozen plasma with fraxiparin is the most rational basic therapy for the first and third clinical pathogenetic variants of subacute disseminated intravascular coagulation in multiple-modality treatment of severe craniocerebral injury. In the second variant of this condition, high doses of proteinase inhibitors in combination with minimum heparin doses are the most rational.

[Clinico-pathogenetic variants of DIC syndrome in patients with severe craniocerebral trauma].

Detection of clinical and pathogenetic variants of the DIC syndrome for development of its differentiated therapy in multiple-modality treatment of severe craniocerebral injury was the purpose of this study. A total of 170 patients with grave craniocerebral injury were examined. The hemostasis system was studied by the following methods: analysis of platelet hemostasis, general coagulation tests, fibrinolysis evaluation, detection of physiological anticoagulants and markers of intravascular blood coagulation and fibrinolysis.

[The rheological properties of the blood in patients with tick-borne typhus].

Rheological characteristics of blood were studied in 50 patients with north Asian tick typhoid varying in severity and duration. In addition to standard diagnosis--verification tests, blood macrorheological and microrheological examinations were made (blood viscosity, hematocrit and red cell deformability and aggregation, respectively). It was found that both in the acute disease and recovery there were changes in blood and plasma viscosity red cell hardness.

[Thrombocytic hemostasis in patients with severe craniocerebral trauma].

Platelet vascular hemostasis was assessed in 32 patients with slight craniocerebral injuries (SCCI) (Glasgow coma score 14-15) (group 1) on days 1, 3, 5, and 7 and in 84 patients (score 3-8) (group 2) in the same terms and on days 9, 14, and 21 after the injury. Under study were platelet count, spontaneous platelet aggregation and that induced by ADP, adrenalin, and ristomicin. Moderate disorders of platelet vascular hemostasis were revealed in all the patients; they were most of all expressed on day 5 and were mainly due to moderate disorders of the athrombogenicity of the vascular endothelium.

[The possible mechanisms of a fibrinolytic disorder in patients with severe craniocerebral trauma].

Fibrinolysis components were studied in 32 patients with slight and 38 ones with grave craniocerebral injuries on days 1, 3, 5, and 7 after the injury. No expressed disorders of blood fibrinolytic activity were revealed in patients with slight injuries. Grave craniocerebral injuries were associated with disorders of the plasmin system.

[Diagnosis and treatment of DIC syndrome in patients with severe craniocerebral trauma].

The hemostasis parameters are compared in 32 patients with slight (14-15 Glasgow score) and 114 with grave craniocerebral injury (3 to 7 Glasgow score) on days 1, 3, 5, and 7 after the injury. Assessment of hemostasiograms revealed a regular development of disseminated intravascular blood coagulation (DIC) in patients with grave craniocerebral injury, whereas in patients with slight injury the changes in the hemostasis system were compensatory. Early (starting from day 1) addition of anticoagulants, disaggregants, and fresh-frozen plasma to treatment protocols are advisable for patients with grave craniocerebral injuries.

[The effect of transcardiac galvanization on the size of the necrotic mass and on the central hemodynamic indices in patients with an acute myocardial infarct].

The authors examined 110 males and females admitted to hospital within 6 hours since the onset of new macrofocal anterior myocardial infarction running without complications. All the patients underwent transcardiac galvanization (TG) in the initial disease hours. Precardiac mapping, tetrapolar rheography and clinical observation provided evidence on TG course action on the necrosis mass, central hemodynamics and clinical appearance of the disease in the acute and postinfarction periods.

[The characteristics of the action of a direct electric (galvanic) current on the ultrastructure of the normal perfused isolated heart and during its postischemic reperfusion].

The effect of direct electric current (DEC), 0.4 mA, on the ultrastructure of normal perfusing isolated heart and in the course of its postischemic reperfusion was studied on the model of isolated rat heart using Langedorf method. DEC was shown to exert a normalizing, membrane-stabilizing effect on the subcellular organization of isolated heart CMC in the course of its normothermic perfusion.

[Radiothermometric monitoring of the dynamics of wound process in the eye].

Measurement of the temperature reaction in the depth of the injured eye by the thermal contrast technique in the UHF band with the use of a radiometer permits monitoring the time course of the wound process in the eye, specify the treatment strategy, forecast the possible complications associated with the treatment and the terms of convalescence.

[Recognition of the disseminated intravascular coagulation syndrome: methodology and expert assessment].

Basing on the results of follow-up of 700 patients suffering from various forms of this syndrome (DIC syndrome), the authors have developed an algorithm and criteria for the expert evaluation of the diagnostic evidence of this condition with specification of the confidence measures for E. Shortliffe's equation. The major classes of evidence have been distinguished, including the causes and clinical situations leading to the development of the DIC syndrome (class A); manifestations of the syndrome--microcirculation blocking, organ ischemias and dysfunctions, thrombohemorrhages, etc.

[Diagnostic criteria in the DIC syndrome and their validation using modern mathematical methods].

The informative value of each of 15 laboratory indices (the amount of platelets, their factor 4 (PF-4), antithrombin III (AT III), fibrinogen and its degradation products (FDP), ethanol and protamine sulfate tests (ET, PST), plasminogen, the eucaryne test, etc.), most commonly used now in laboratory practice for the diagnosis of the DIC syndrome was assessed using mathematical methods relating mainly to the theory of pattern recognition. Basic and alternative algorithms of the recognition of the DIC syndrome which could be used with a minor error (less than or equal to 2.

[Effect of various concentrations of 3H-thymidine on the kinetics of Chinese hamster cell division].

A study of the asynchronous culture of Chinese hamster fibroblasts by autoradiography has shown that the pulse (15 min) incorporation of 3H-thymidine in nuclear DNA influences the kinetics of labeled cell proliferation. The results obtained suggest that one of the early biological effects of the pulse incorporation of 3H-thymidine is a delay in the occurrence of the first mitosis. With the concentration of 3H-thymidine 37 kBq/ml the slowing down of of the movement of labeled cells in the cycle is detected by a shift and overlapping of waves of labeled and unlabeled mitotic cells.

[Comparative study of various rapid methods of determining fibrinogen transformation products in the diagnosis of intravascular coagulation and fibrinolysis].

Rapid methods for determination of fibrin-monomer complexes and fibrinogen/fibrin degradation products were studied and compared in 76 patients with different abnormalities in the hemostatic system (acute thromboses, thromboembolism of the pulmonary artery, disseminated intravascular coagulation, immune thrombovasculitis, etc). The control group consisted of 36 healthy donors. The fibrin-monomer complexes were determined by the paracoagulation tests, the ethanol test (ET) and protamin sulfate tests (PST), whereas fibrinogen/fibrin degradation products (FDP) by the staphylococcus adhesion test (SAT) in which use was made of the Newman D2S strain variety obtained by the authors.

[Unscheduled DNA synthesis during gamma-irradiation of human lymphocytes in the G1 stage].

A study was made of the unscheduled synthesis of DNA in gamma-irradiated nuclei of human lymphocytes 10, 15 and 20 hr following PHA-stimulation. It was shown that the unscheduled DNA synthesis is a function of radiation dose and time after PHA-stimulation.

[Effect of the time before fixation on the yield of chromosome aberrations in a culture of human lymphocytes exposed to gamma rays at different stages of the mitotic cycle].

A comparative study was made of the yield of chromosome aberrations in human lymphocyte culture exposed to 60Co-gamma-rays (2 Gy) at different mitotic cycle stages the cells being fixed after 52 and 60 hr. It was shown that with the latter fixation time (60 hr) the frequency of chromosome aberrations after irradiation in G1 stage was substantially lower than that with the former one (52 hr) and, vice versa, it was higher after irradiation in S and G2 stages. The authors discuss the probable causes of the distinctions observed.