Mathematical analysis of subtypes of muscarinic receptors modulating heart and respiratory rhythms in rats.

Mathematical analysis of the data obtained in experiments on the whole organism revealed that blockade of M(2)-cholinergic receptors increased both heart and respiratory rates. Blockade of M(1)-cholinergic receptors alleviated tachycardia induced by M(2)-receptor blockade.

Experimental study of biological activity of angiogen in experimental cardiovascular and hemostasis pathology.

Positive effects of angiogen, a preparation containing succinic and acetylsalicylic acids, on ECG, blood clotting, and lipid metabolism were demonstrated on animals with experimental cardiovascular disease induced by repeated injections of norepinephrine.

[The evaluation of the specific activity and side effects of the m-cholinergic blocker pentifin compared to other antiparkinson agents].

Experiments on rodents showed that pentifin, a muscarine antagonist belonging to the group of acetylene amines, possesses a pronounced antiparkinsonian activity. Pentifin is superior in the breadth of therapeutic action and tolerance characteristics to the conventional agents used for Parkinson's disease treatment.

[An experimental model of benzodiazepine intoxication].

It has been demonstrated in rat experiments that intraperitoneal injection of 100 mg/kg phenazepam immobilizes the animals for one hour, causes long-term diminution of the muscular tonus and disturbed coordination of movements, tachycardia, hypotension, hyperthermia, depression of orientation and exploration motor activity, and disturbance of conditioned reflexes of active and passive avoidance. It is concluded that the changes in the above-indicated parameters of autonomic and behavioral status of rats under the effect of a 100 mg/kg dose of phenazepam are clearly expressed for a long period of time, are specific to the effect of benzodiazepines and may therefore serve as a model of severe BD intoxication for evaluating the efficacy of their antidotes. This has been confirmed in experiments with the well-known BD antagonist phlumazelin.

[The role of blockage of various M-cholinoreceptor subtypes in induction of tachycardia in rats].

The mechanism of the effect of M-cholinoblockers on the heart rate was analysed. It is suggested on the basis of this analysis that tachycardia induced in reats by muscarinic antagonists was caused by blockade of ther central M1-cholinoceptors which is accompanied with increase in the tone of the sympathetic branch of the autonomic nervous system.

[Behavioral effects of thyroliberin on animals of various species].

It has been shown that there are some significant differences in behavioural effects of exogenous thyroliberin for different mammals (mice, rats, dogs, monkeys). The necessity of a careful preclinical trial of peptide drugs is discussed.