Publications by authors named "Lyall Glait"
Article Synopsis
- Mitochondrial calcium (Ca) handling is regulated through a balance of Ca uptake via the mitochondrial calcium uniporter (MCU), Ca buffering, and efflux via exchangers like Na/Ca (NCLX) and Ca/H (CHE) exchangers.
- This study examined Ca efflux through CHE in rat cardiac mitochondria, finding that factors like the amount of matrix Ca and external pH significantly influence this process, with acidic pH enhancing Ca efflux and ADP reducing it.
- Results suggest that the CHE's role in cardiac mitochondria is more complex than previously thought, potentially involving interactions with matrix Ca levels and pH changes, along with a potential contribution from LETM1
Electrical stimulation of the central and peripheral nervous systems - such as deep brain stimulation, spinal cord stimulation, and epidural cortical stimulation are common therapeutic options increasingly used to treat a large variety of neurological and psychiatric conditions. Despite their remarkable success, there are limitations which if overcome, could enhance outcomes and potentially reduce common side-effects. Micromagnetic stimulation (μMS) was introduced to address some of these limitations.
View Article and Find Full Text PDFThe purpose of this study was to test whether a Kv3 potassium channel modulator, AUT00063, has therapeutic potential for reversing noise-induced increases in spontaneous neural activity, a state that is widely believed to underlie noise-induced tinnitus. Recordings were conducted in noise exposed and control hamsters from dorsal cochlear nucleus (DCN) fusiform cells before and following intraperitoneal administration of AUT00063 (30 mg/kg). Fusiform cell spontaneous activity was increased in sound-exposed animals, approximating levels that were nearly 50% above those of controls.
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