Predicting executive functioning from brain networks: modality specificity and age effects.

Healthy aging is associated with structural and functional network changes in the brain, which have been linked to deterioration in executive functioning (EF), while their neural implementation at the individual level remains unclear. As the biomarker potential of individual resting-state functional connectivity (RSFC) patterns has been questioned, we investigated to what degree individual EF abilities can be predicted from the gray-matter volume (GMV), regional homogeneity, fractional amplitude of low-frequency fluctuations (fALFF), and RSFC within EF-related, perceptuo-motor, and whole-brain networks in young and old adults. We examined whether the differences in out-of-sample prediction accuracy were modality-specific and depended on age or task-demand levels.

Brain functional characterization of response-code conflict in dual-tasking and its modulation by age.

Crosstalk between conflicting response codes contributes to interference in dual-tasking, an effect exacerbated in advanced age. Here, we investigated (i) brain activity correlates of such response-code conflicts, (ii) activity modulations by individual dual-task performance and related cognitive abilities, (iii) task-modulated connectivity within the task network, and (iv) age-related differences in all these aspects. Young and older adults underwent fMRI while responding to the pitch of tones through spatially mapped speeded button presses with one or two hands concurrently.

Predicting Executive Functioning from Brain Networks: Modality Specificity and Age Effects.

Healthy aging is associated with structural and functional network changes in the brain, which have been linked to deterioration in executive functioning (EF), while their neural implementation at the individual level remains unclear. As the biomarker potential of individual resting-state functional connectivity (RSFC) patterns has been questioned, we investigated to what degree individual EF abilities can be predicted from gray-matter volume (GMV), regional homogeneity, fractional amplitude of low-frequency fluctuations (fALFF), and RSFC within EF-related, perceptuo-motor, and whole-brain networks in young and old adults. We examined whether differences in out-of-sample prediction accuracy were modality-specific and depended on age or task-demand levels.

Response-code conflict in dual-task interference and its modulation by age.

Difficulties in performing two tasks at once can arise from several sources and usually increase in advanced age. Tasks with concurrent bimodal (e.g.