High prevalence of soil-transmitted helminths among primary students in Ha Giang, Vietnam: A descriptive cross-sectional study.

Despite improvements in environmental sanitation and healthcare, the infection rate of soil-transmitted helminths (STHs) remains high in low socioeconomic regions of developing countries including Vietnam. This study aimed to determine the prevalence and intensity of STH infections among primary school children in Meo Vac, Ha Giang: a poor mountainous province in Vietnam. A descriptive cross-sectional study was conducted from October to November 2023, involving 400 participants.

Health-related Quality of Life Among Comorbidity Patients With Type 2 Diabetes Mellitus and Hypertension.

Background: Evaluating the Health-Related Quality of Life (HRQoL) in patients with hypertension and diabetes is vital for improving treatment adherence and outcomes.

Objective: This study assessed HRQoL and its influencing factors among patients with both type 2 diabetes mellitus and hypertension at Can Tho Hospital, Vietnam.

Methods: A cross-sectional study was performed on 310 outpatients at the polyclinic, using the Short Form-36 Health Survey (SF-36) between July 2021 and July 2022.

Lignin nano/micro-particles from agricultural biomasses: Developing direct precipitation for integrated biorefinery.

The state-of-the-art, simple and scalable methods for lignin micro-/nano-particles recovery from agricultural biomasses were evaluated in this review. Being non-wood biomasses, these materials can be easily fibrillated, supporting the usage of mild soda or organic solvent pretreatment. Different approaches in particle recovery were compared to conclude that the bottom-up approach facilitates smaller particles towards the nano-size range whereas mechanical treatment can act as a supporting method to increase uniformity and reduce particle sizes after bottom-up precipitation.

A study on tumor necrosis factor-α single nucleotide polymorphisms and psoriasis vulgaris in Vietnam.

This study aims to evaluate the association between tumor necrosis factor-a (TNF-α) single nucleotide polymorphisms and psoriasis vulgaris. This cross-sectional study involved 140 Vietnamese patients of Kinh ethnicity diagnosed with psoriasis vulgaris. The diagnosis of psoriasis vulgaris was based on clinical signs and symptoms.

Large-Area Aligned Growth of Low-Symmetry 2D ReS on a High-Symmetry Surface.

The large-scale preparation of two-dimensional (2D) materials is pivotal in unlocking their extensive potential for next-generation semiconductor device applications. Wafer-scale single crystals of a high-symmetry 2D material (e.g.

Co-design of an electronic patient-reported outcome symptom monitoring system for immunotherapy toxicities.

Background: Utilising electronic patient-reported outcomes (ePRO) to monitor symptoms can improve patient outcomes. However, ePRO systems are typically not co-designed with end-users which may limit their utility and long-term sustainability. We aimed to co-design a real-time ePRO symptom monitoring system for immune checkpoint inhibitor (ICI) toxicities.

Strategic Design for High-Efficiency Oxygen Evolution Reaction (OER) Catalysts by Triggering Lattice Oxygen Oxidation in Cobalt Spinel Oxides.

High-efficiency catalysts with refined electronic structures are highly desirable for promoting the kinetics of the oxygen evolution reaction (OER) and enhancing catalyst durability. This study comprehensively explores strategies involving metal doping and oxygen vacancies for enhancing the acidic OER catalytic activity of CoO. Through extensive screening of 3d and 4d transition metals using density functional theory (DFT) simulations, we demonstrate that the incorporation of metal dopants and oxygen vacancies into CoO potentially triggers a transition from the adsorbate evolution mechanism (AEM) to the lattice oxygen oxidation mechanism (LOM) in the oxygen evolution reaction (OER).

Double-Stacked One-Third Tubular Plating for Suprasyndesmotic Fibula Fractures Technique Description and Clinical Case Series.

Fixation for suprasyndesmotic fibula fractures (AO/OTA type 44C, consistent with Weber C) is classically achieved using a single one-third tubular plate. However, these fractures may sometimes require stronger fixation due to the diaphyseal fracture location and the lack of structural support from injured ligaments. To increase stability, 3.

Copper-Catalyzed Cascade Cyclization of 2-Nitrochalcones with NH-Heterocycles.

We developed a method for allowing cascade cyclization of 2-nitrochalcones with pyrazoles, imidazole, and indazole in the presence of CuI catalyst, DBU base, and THF solvent. The conditions were tolerant of an array of useful functionalities including ester, nitro, cyano, halogen groups. A mechanistic consideration was also provided, as HO was presumably a byproduct.

Exploring the Endothelin-1 pathway in chronic thromboembolic pulmonary hypertension microvasculopathy.

Targeted vasopeptide therapies have significantly advanced the management of pulmonary arterial hypertension (PAH). However, due to insufficient preclinical evidence regarding the involvement of the endothelin-1 (ET-1) pathway in chronic thromboembolic pulmonary hypertension (CTEPH) pathophysiology, the potential of ET-1 receptor antagonism in treating CTEPH remains uncertain. In this study, we investigated the role of the ET-1 pathway in CTEPH microvasculopathy using a multifaceted approach.

Early treatment of skeletal class III malocclusion with facemask therapy in Vietnam.

To evaluate the effects of facemask therapy on skeletal class III malocclusion in the Vietnamese population. This interventional trial enrolled a total of 31 children, dividing them into two age groups: Children aged 7 to 9 (54.8%), who were in the pre-pubescent or early mixed dentition stages, comprised one group.

New CYP154C4 from Streptomyces cavourensis YBQ59 performs regio- and stereo- selective 3β-hydroxlation of nootkatone.

Nootkatone, a sesquiterpenoid widely used in the food and cosmetics industries, exhibits diverse biological activities and pharmaceutical prospects. Modification of nootkatone to create new derivatives with desirable activities has attracted significant attention. For this purpose, cytochrome P450 monooxygenases (P450 or CYP) are attractive candidates due to their ability to perform regio- and stereoselective hydroxylation at allylic C-H bonds.

Application of a metatranscriptomics technology, CSI-Dx, for the detection of pathogens associated with prosthetic joint infections.

Preoperative identification of causal organism(s) is crucial for effective prosthetic joint infection treatment. Herein, we explore the clinical application of a novel metatranscriptomic (MT) workflow, CSI-Dx, to detect pathogens associated with prosthetic joint infection. MT provides insight into transcriptionally active microbes, overcoming limitations of culture-based and available molecular methods.

Efficacy and Safety of a Tubeless AID System Compared With Pump Therapy With CGM in the Treatment of Type 1 Diabetes in Adults With Suboptimal Glycemia: A Randomized, Parallel-Group Clinical Trial.

Objective: To examine the efficacy and safety of the tubeless Omnipod 5 automated insulin delivery (AID) system compared with pump therapy with a continuous glucose monitor (CGM) in adults with type 1 diabetes with suboptimal glycemic outcomes.

Research Design And Methods: In this 13-week multicenter, parallel-group, randomized controlled trial performed in the U.S.

Glycaemic outcomes in adults with type 2 diabetes over 34 weeks with the Omnipod® 5 Automated Insulin Delivery System.

Aims: The aim was to evaluate the effect of extended use of the Omnipod® 5 Automated Insulin Delivery (AID) System in adults with type 2 diabetes and suboptimal glycaemic control.

Materials And Methods: Following an 8-week single-arm, multicentre, outpatient trial of AID in adults with type 2 diabetes and baseline HbA1c ≥ 8% (≥ 64 mmol/mol), participants were given the opportunity to continue use of the AID system in a 26-week (~6 month) extension phase. The primary safety endpoints were percentage of time with sensor glucose ≥ 250 mg/dL and < 54 mg/dL.

Comprehensive Exploration of Bromophenol Derivatives: Promising Antibacterial Agents against SA and MRSA.

The incidence of treatment failure due to multidrug-resistant pathogens elevated over the years; the rate is much higher than new antibiotic drug discovery. Therefore, bromophenol derivatives as potential antibacterial agents on and MRSA were explored in this research via integrating chemistry, microbiology, and pharmacology to address significant knowledge gaps pertaining to the antibacterial activity of bromophenols based on their functional groups. Surprisingly, a simple molecule, 3-bromo-2,6-dihydroxyacetophenone (), exhibited good anti- activity and even MRSA, a drug-resistant strain.

Psychosocial outcomes with the Omnipod® 5 Automated Insulin Delivery System in caregivers of very young children with type 1 diabetes.

Aim: Automated insulin delivery (AID) systems have demonstrated improved glycaemic outcomes in people with type 1 diabetes (T1D), yet limited data exist on these systems in very young children and their impact on caregivers. We evaluated psychosocial outcomes following use of the tubeless Omnipod® 5 AID System in caregivers of very young children.

Materials And Methods: This 3-month single-arm, multicentre, pivotal clinical trial enrolled 80 children aged 2.

Using targeted proteomics-based detection of collagen propeptides to quantify fibrillar collagen biogenesis in vitro.

The collagen superfamily, as the major structural component of the extracellular matrix, encompasses 28 distinct subtypes, with type-I and -III forming fibrils crucial for the matrix scaffold. During collagen biogenesis, trimers of type-I and -III procollagen are secreted into the extracellular matrix. The N- and C-terminal propeptides of these trimers are proteolytically cleaved from procollagen during secretion, initiating collagen fibril formation.

Three versus six weeks of post-amputation antibiotic therapy in diabetic forefoot osteomyelitis with positive culture for residual infected bone.

Objectives: In 2021 in our university hospital, it was decided in a multidisciplinary consultation meeting on osteoarticular infection in patients with diabetic foot to reduce the duration of post-amputation antibiotic therapy from six to three weeks in patients with diabetic forefoot osteomyelitis and residual bone infection. This study aimed to compare clinical outcomes in this group of patients, before vs after the change in practice introduced in 2021.

Methods: In this before-after study, we included all cases reported between January 2016 and August 2023 in the University Hospital of Reims.