Clinical serum lipidomic profiling revealed potential lipid biomarkers for early diabetic retinopathy.

Diabetic retinopathy (DR) is a serious complication of diabetes featuring abnormal lipid metabolism. However, the specific lipid molecules associated with onset and progression remain unclear. We used a broad-targeted lipidomics approach to assess the lipid changes that occur before the proliferative retinopathy stage and to identify novel lipid biomarkers to distinguish between patients without DR (NDR) and with non-proliferative DR (NPDR).

Application of pesticide application measures to reduce residue based on the metabolic transfer law of imidacloprid in banana leaves and soil.

An investigation of the metabolism and transfer of imidacloprid (IMI) in banana plants and soil was performed using high-resolution mass spectrometry. Results indicated the presence of eight IMI metabolites in soil and leaves that resulted from hydroxylation of the imidazolidine ring, the reduction and loss of nitro groups, and oxidative cleavage of methylene bridges. Six metabolites, including 4/5-hydroxy IMI (4/5-hydroxy), IMI olefin (olefin), and 6-chloronicotinic acid (6-CNA), were detected in the fruits following leaf treatment, while only three were detected after soil treatment.

Adsorption behavior of azole fungicides on polystyrene and polyethylene microplastics.

Agricultural plastic films and triazole fungicides are widely used in agricultural production process. Exposure to natural environment, agricultural plastic films will degrade into micron plastic particles, which will adsorb pesticide molecules and may affect their toxicity, biological activity and persistence. The long-term coexistence of microplastics (MPs) and triazole fungicides will bring potential harms to the agricultural ecological environment.

Construction of a magnetic solid-phase extraction method for the analysis of azole pesticides residue in medicinal plants.

In this work, a sensitive and cost-effective method for the quantitative analysis of azole pesticides residues in six medicinal plants was established based on magnetic cyclodextrin crosslinked with tetrafluoroterephthalonitrile (FeO@TFN-CDPs) coupled with high-performance liquid chromatography (HPLC). Through characterization analysis, the outer shell of FeO@TFN-CDPs has observed coating with a network of the polymer and forming a core-shell structure. Under the optimum conditions, the limits of detection (LODs) and limits of qualification (LOQs) of target pesticides were ranged from 0.