Publications by authors named "Lvye Gao"
Article Synopsis
- The study explored how SF3B1 contributes to non-small cell lung cancer (NSCLC), particularly lung adenocarcinoma (LUAD), highlighting its role in tumor growth and spread.
- Elevated SF3B1 levels in LUAD were linked to worse outcomes, including greater lymph node metastasis, and experimental manipulation of SF3B1 influenced cancer cell behavior.
- The research identified that SF3B1 helps LUAD cells resist ferroptosis, a type of cell death, by regulating specific genes and pathways, revealing potential targets for therapeutic intervention.
Lysosomal dysfunction can drive carcinogenesis. Lysosomal-associated membrane protein 3 (LAMP3), is a member of the Lysosome Associated Membrane Proteins and is involved in the malignant phenotype such as tumour metastasis and drug resistance, while the mechanisms that regulate the malignant progression of tumour remain vague. Our study aims to provide a more systematic and comprehensive understanding of the role of LAMP3 in the progression of various cancers by various databases.
View Article and Find Full Text PDFBackground: TSTA3 gene encoding GDP-L-fucose synthase has recently been proved to be closely related to the prognosis of patients with various tumors. However, its role in lung cancer is still unclear. The purpose of this study is to explore the expression level, prognostic effect, potential function and mechanism of TSTA3 in lung cancer.
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