Publications by authors named "Lvsha Xie"
LL37-DNA Complex Drives Vitiligo Progression Through TLR9-MyD88 Signaling Pathways.
Pigment Cell Melanoma Res
January 2025
Article Synopsis
- Vitiligo is an autoimmune condition that leads to white patches on the skin due to the destruction of melanocytes by CD8 T cells, influenced by various immune-related factors.
- The study found increased levels of LL37, a molecule linked to autoimmune diseases, in the blood and skin lesions of vitiligo patients.
- LL37 may contribute to melanocyte loss by enhancing certain inflammatory signals and helping CD8 T cells migrate, particularly under conditions of oxidative stress.