[Sleep disorders and oncological diseases].

The study of neurological symptoms and signs connected with neoplasms and antitumor therapy is relevant in the context of an increasing prevalence of cancer. The COVID-19 pandemic and social factors have increased the number of patients suffering from insomnia. Sleep disorders is an unfavorable prognostic factor for neoplasms.

The Aha! experience is associated with a drop in the perceived difficulty of the problem.

The study investigated the correlation between the intensity of the Aha! experience and participants' subjective difficulty ratings of problems before and after finding their solutions. We assumed that the Aha! experience arises from a shift in processing fluency triggered by changing from an initially incoherent problem representation to a coherent one, which ultimately leads to the retrieval of a solution with unexpected ease and speed. First, we hypothesized that higher Aha! experience ratings would indicate more sudden solutions, manifesting in a reduced correlation between the initial difficulty ratings and solution times.

Dabigatran in the treatment and secondary prophylaxis of venous thromboembolism in children with thrombophilia.

In the phase 2b/3 DIVERSITY trial, 3 months treatment with dabigatran was noninferior to standard of care (SOC) for acute venous thromboembolism (VTE) in children. In a single-arm, phase 3, secondary VTE prevention study, up to 12 months dabigatran use was associated with favorable safety. Dabigatran is approved by the European Medicines Agency and US Food and Drug Administration for pediatric indications.

How Difficult Was It? Metacognitive Judgments About Problems and Their Solutions After the Aha Moment.

The insight phenomenon is thought to comprise two components: cognitive and affective (the Aha! experience). The exact nature of the Aha! experience remains unclear; however, several explanations have been put forward. Based on the processing fluency account, the source of the Aha! experience is a sudden increase in processing fluency, associated with emerging of a solution.

Interpretable and Continuous Prediction of Acute Kidney Injury in the Intensive Care.

Acute kidney injury (AKI) is a common and potentially life-threatening condition, which often occurs in the intensive care unit. We propose a machine learning model based on recurrent neural networks to continuously predict AKI. We internally validated its predictive performance, both in terms of discrimination and calibration, and assessed its interpretability.

Safety and efficacy of rivaroxaban in pediatric cerebral venous thrombosis (EINSTEIN-Jr CVT).

Anticoagulant treatment of pediatric cerebral venous thrombosis has not been evaluated in randomized trials. We evaluated the safety and efficacy of rivaroxaban and standard anticoagulants in the predefined subgroup of children with cerebral venous thrombosis (CVT) who participated in the EINSTEIN-Jr trial. Children with CVT were randomized (2:1), after initial heparinization, to treatment with rivaroxaban or standard anticoagulants (continued on heparin or switched to vitamin K antagonist).

LPDs - «Linked to penumbra» discharges or EEG correlate of excitotoxicity: A review based hypothesis.

Periodic lateralized epileptiform discharges (PLEDs) or lateralized periodic discharges (LPDs) are a well-known variant of pathological EEG activity. However, the mechanisms underpinning the appearance of this pattern are not completely understood. The heterogeneity of the features derived from LPDs patterns, and the wide range of pathological conditions in which they occur, raise a question about the unifying mechanisms underlying these phenomena.

Rivaroxaban compared with standard anticoagulants for the treatment of acute venous thromboembolism in children: a randomised, controlled, phase 3 trial.

Background: Treatment of venous thromboembolism in children is based on data obtained in adults with little direct documentation of its efficacy and safety in children. The aim of our study was to compare the efficacy and safety of rivaroxaban versus standard anticoagulants in children with venous thromboembolism.

Methods: In a multicentre, parallel-group, open-label, randomised study, children (aged 0-17 years) attending 107 paediatric hospitals in 28 countries with documented acute venous thromboembolism who had started heparinisation were assigned (2:1) to bodyweight-adjusted rivaroxaban (tablets or suspension) in a 20-mg equivalent dose or standard anticoagulants (heparin or switched to vitamin K antagonist).

[Specifics of visual perception in infants with familial risk of autism spectrum disorders].

Preclinical prediction of autistic spectrum disorders (ASD) is one of the priorities of current research. Children at risk of ASD develop an atypical visual perception profile early in their lives, which influences their visual responsiveness, distribution of attention, and social orienting. In this study we have compared the oculomotor behavior in an infant at familial risk of ASD with data from two 10-month infants with typical development.

[Predictors of epilepsy in children after ischemic stroke].

Aim: To determine clinical/instrumental predictors of symptomatic epilepsy after ischemic stroke in children.

Material And Methods: One hundred and thirty-six patients, aged 0-15 years, with the diagnosis of ischemic stroke (ICD-10 I63.0-I63.

[The assessment of neurocognitive functions in premature infants in the first year of life using Bayley Scales].

Aim: To reveal the differences in neurocognitive development in premature infants and full-term infants in the first year of life.

Material And Methods: The participants were 17 premature infants and 16 sex- and age-matched healthy full-term infants. The gestational age of preterm infants was between 28 and 36 weeks.

[Clinical manifestations of the onset and diagnostic problems in children with moyamoya disease].

Moyamoya disease in children is a rarely diagnosed entity. Frequent headache is the first symptom of the disease. Headache associated with moya-moya disease (HAMD) is a separated entity reported in the literature.

[The inherited procoagulant and prothrombotic condition as the main etiological factor for ischemic stroke in infants].

The data on the risk factors and etiology of ischemic stroke in 31 infants, aged under 3 years, are summarized. The results of genotyping of blood coagulation and folic acid gene polymorphisms in patients and 83 healthy people are presented. Significant differences were found for -455 G>A FGB (р=0.

[Gene-determined hemocoagulation disease as a cause of ischemic stroke in children].

History of thrombosis and polymorphisms of genes of hemocoagulation system were studied in 27 children with ischemic stroke. The distribution of allelic variants in the Russian population was compared to that in other world populations. Each patient had 4 and more allelic variants of hemocoagulation's genes.

[The prevalence of eating behavior disorders in patients with overweight and obesity].

Unlabelled: The prevalence of food behavior abnormalities among people with overweight and obesity. The

Aim Of Investigation: To estimate characteristics of food behaviour among people with overweight and obesity.

Materials And Methods: We examined 188 human of Chuvashia.

Relationship between alcohol motivation and ethanol sensitivity and blood and brain catecholamine content in the progeny of rats preferring and nonpreferring alcohol.

A system of neurochemical signs indicating predisposition to high ethanol consumption is formed in the third generation descendants of ethanol-preferring male rats. Risk-group males are detected (with 95% probability) by the content of dopamine and norepinephrine and their ratio in the brain. Alcohol motivation depends on blood epinephrine content reflecting individual sensitivity to stress.

[The neurochemical mechanisms underlying possible recurrences of alcoholism].

Experiments on chronic alcoholized rats revealed the similar changes in brain dopamine receptors, in brain and blood catecholamines as well as in blood cyclic adenosine monophosphate during both short- and long-term alcohol deprivation. It is concluded that such changes may form material basis for alcoholism relapses.

[The quantitative analysis of lipopolysaccharide antigen in the blood serum of patients with salmonellosis by using complement-bound liposome lysis].

Titration of group B Salmonella O-antigen in the blood sera of patients and donors was carried out by means of the complement-dependent lysis of liposomes sensitized with S. typhimurium LPS. Good correlation (r = 0.

[Effect of luminescence quenchers on the maximum concentration of radicals in proteins following UV-irradiation (77 K)].

It has been shown that the limiting number of ionization acts (z) in a protein molecule in water solution UV-irradiated at 77 K is in proportion to the molecular weight: z=8.10(-6) M. Only one ionization is possible in simple protein with M=12,5.