Non-culprit plaque healing on serial OCT imaging and future outcome in patients with acute coronary syndromes.

Background And Aims: Histologic studies indicated that healed plaque, characterized by a multilayered pattern, is indicative of prior atherothrombosis and subsequent healing. However, longitudinal in vivo data on healed plaque formation in non-culprit plaques are limited. This study aimed to investigate serial changes and clinical significance of new layered pattern formation in non-culprit plaques in patients with acute coronary syndromes (ACS) using serial optical coherence tomography (OCT) imaging.

Furan-based renewable elastomers as effective tougheners for PLA: Enhanced mechanical properties and water vapor barrier properties.

There is a great need for versatile biomass additives sourced from renewable materials to enhance the performance of polylactic acid (PLA) composites. This study introduces a furan-based polyester elastomer called PNF-PBC that is designed to improve the mechanical and water vapor barrier characteristics of PLA. By incorporating PNF-PBC into PLA, the toughness of the PLA/PNF-PBC biocomposites was considerably enhanced through various intermolecular interactions.

Comprehensive improvements in the emergency laboratory test process based on information technology.

Objective: To explore the application effects of information technology (IT) on emergency laboratory testing procedures.

Methods: In this study, IT-based optimisation of the emergency laboratory testing process was implemented between October and December 2021. Thus, the emergency laboratory test reports from January to September 2021 were placed into the pre-optimised group, while those from January to September 2022 were categorised into the post-optimised group.

Lnc AC016727.1/BACH1/HIF-1 α signal loop promotes the progression of non-small cell lung cancer.

Background: Long noncoding RNAs (lncRNAs) have been reported to play vital roles in the development and progression of cancer. However, their biological significance and functional mechanisms in non-small cell lung cancer (NSCLC) are mostly unclear.

Methods: We performed RNA-sequencing to predict the differential expression of lncRNAs in clinical NSCLC and paired paracancerous lung tissues.

Investigating the synergistic effects of magnesia-coal slag based solid waste cementitious materials and its basic characteristics as a backfill material.

Applying solid waste resources as backfill material can reduce both the cost of backfill and the environmental problems caused by solid waste landfills. In this paper, the synergistic reaction effects of solid waste modified magnesia slag (MMS), coal gasification slag (CGS), and desulfurized gypsum (DG) as magnesium-coal slag based cementitious materials (MCC) and their preliminary feasibility as mining cementitious materials in synergy with coal gangue for the preparation of backfill materials are investigated. The results show that the order of the compressive strength of the cementitious systems is ternary system > binary system > monolithic system, which proves the existence of synergistic effect among MMS, CGS, and DG and determines the optimal dosing of each raw material in the ternary system.

Basic characteristics of magnesium-coal slag solid waste backfill material: Part I. preliminary study on flow, mechanics, hydration and leaching characteristics.

The environmental damage caused by surface subsidence and coal-based solid waste (CBSW) is a common problem in the process of coal mining. Backfill mining can control the mining-induced subsidence and solve the problem of bulk solid waste storage. In the present work, a magnesium-coal slag solid waste backfill material (MCB) with modified magnesium slag (MS) as binder and CBSW (fly ash (FA), flue gas desulfurization gypsum (FDG) and coal gasification slag (CGS)) as supplementary cementitious material/aggregate was proposed to meet the needs of coal mining in Northern Shaanxi, China, to realize the comprehensive treatment of goaf and CBSW.

Experimental Study on Early Strength and Hydration Heat of Spodumene Tailings Cemented Backfill Materials.

Spodumene tailing is the associated solid waste of extracting lithium from spodumene. With the increase in the global demand for lithium resources, its emissions increase yearly, which will become a key factor restricting the economic development of the mining area. Mechanical and hydration reactions, as well as the microstructure of early CSTB, are studied under different tailings-cement ratios (TCR) and solid mass concentration (SC) conditions.

Endostar Synergizes with Radiotherapy to Inhibit Angiogenesis of Cervical Cancer in a Subcutaneous Xenograft Mouse Model.

Background: To investigate the synergic effect and underlying mechanism of Endostar, a recombinant human endostatin used for anti-angiogenesis, in radiotherapy for cervical cancer.

Methods: The Cell Counting Kit-8 (CCK-8) assay and plate cloning experiment were first employed to analyze the proliferation of HeLa and SiHa cervical cancer cells and human umbilical vein vascular endothelial cells (HUVECs). Flow cytometry was used to detect apoptosis and cell cycle progression.

Mortality Risk factors and SOX2 and mTOR expression in Patients with Esophageal Cancer.

Causes of mortality in EC patients are not confined to cancer-specific mortality but include various protein expressions of SOX2 and mTOR in Esophageal Cancer patients and their correlation with the clinical stage. Data about the risk factors and involvement of cancer-specific protein are still lacking. This study aimed to define the risk factors and association of SOX2 and mTOR expression in mortality in patients with EC.

Inspiratory hyperoxia suppresses lung cancer metastasis through a MYC/SLC1A5-dependent metabolic pathway.

The lack of knowledge about the effect of inspiratory hyperoxia on the lung-specific tumour microenvironment and progression of lung cancer has attracted considerable attention. This study proposes that inspiratory hyperoxia has special significance for the malignant phenotype of lung cancer cells. The effects of different oxygenation parameters on the proliferation, apoptosis, invasion and migration of lung cancer cells were systematically evaluated and Our results reveal that inspiratory hyperoxia treatment (60% oxygen, 6 h·day) not only has no tumour progression-promoting effects, but also suppresses lung cancer metastasis and promotes long-term survival.

PgtE Enzyme of Shares the Similar Biological Roles to Plasminogen Activator (Pla) in Interacting With DEC-205 (CD205), and Enhancing Host Dissemination and Infectivity by .

, the cause of plague, is a newly evolved Gram-negative bacterium. Through the acquisition of the plasminogen activator (Pla), gained the means to rapidly disseminate throughout its mammalian hosts. It was suggested that utilizes Pla to interact with the DEC-205 (CD205) receptor on antigen-presenting cells (APCs) to initiate host dissemination and infection.

Construction of a Drug Delivery System via pH-Responsive Polymeric Nanomicelles Containing Ferrocene for DOX Release and Enhancement of Therapeutic Effects.

We report an amphiphilic block copolymer via poly(ethylene glycol) methyl ether-D-poly(caprolactone)-ferrocene (mPEG-D-PCL-Fc) to deliver anticancer drug doxorubicin (DOX). Lipase Novozyme-435 was used as a catalyst for ring-opening polymerization with ε-caprolactone, and an acid-sensitive Schiff base was used to connect the hydrophilic and hydrophobic parts; the ferrocene provided ferrous ions and was introduced at the end of the amphiphilic copolymer. The resulting copolymers were characterized by H NMR/C NMR and could be self-assembled in an aqueous solution to form nanomicelles with PCL-Fc as a hydrophobic core and mPEG as a hydrophilic shell.

The Efficacy and Safety of Continuous Intravenous Endostar Treatment Combined With Concurrent Chemoradiotherapy in Patients With Locally Advanced Cervical Squamous Cell Carcinoma: A Randomized Controlled Trial.

Objective: To investigate the short-term efficacy and safety of Endostar combined with concurrent chemoradiotherapy in the treatment of locally advanced cervical squamous cell carcinoma (LACSC).

Methods: A total of 91 patients with LACSC admitted to the First Affiliated Hospital of Anhui Medical University from June 2019 to December 2020 were randomly assigned to either the experimental group (n = 48) or control group (n = 43). The control group received radiotherapy for cervical cancer and paclitaxel combined with platinum chemotherapy (CCRT), and the experimental group received Endostar continuous intravenous infusion of anti-angiogenic therapy plus CCRT.

Loss of the virulence plasmid by promotes its interactions with CD207 and CD209 receptors.

the cause of bacillary dysentery, belongs to Gram-negative enteropathogenic bacteria. contains a 210 kb virulence plasmid that encodes an O-antigen gene cluster of LPSs. However, this virulence plasmid is frequently lost during replication.

Evaluation of deep learning-based auto-segmentation algorithms for delineating clinical target volume and organs at risk involving data for 125 cervical cancer patients.

Objective: To evaluate the accuracy of a deep learning-based auto-segmentation mode to that of manual contouring by one medical resident, where both entities tried to mimic the delineation "habits" of the same clinical senior physician.

Methods: This study included 125 cervical cancer patients whose clinical target volumes (CTVs) and organs at risk (OARs) were delineated by the same senior physician. Of these 125 cases, 100 were used for model training and the remaining 25 for model testing.

Design and Preparation of Molecularly Imprinted Membranes for Selective Separation of Acteoside.

Acteoside (ACT) belongs to a type of phenylethanoid glycosides (PhGs), and it is worthy of obtaining high-purity due to its significant medicinal functions. In this study, a novel class of MIMs was designed and synthesized with PVDF membranes as the base membrane for high selective separation and enrichment of ACT. The effects of the different functional monomers, the amounts of functional monomers, crosslinking agents, and initiators on the separation properties of MIMs were investigated.

Regulation of Cued Fear Expression via Corticotropin-Releasing-Factor Neurons in the Ventral Anteromedial Thalamic Nucleus.

The ventral part of the anteromedial thalamic nucleus (AMv) is in a position to convey information to the cortico-hippocampal-amygdalar circuit involved in the processing of fear memory. Corticotropin-releasing-factor (CRF) neurons are closely associated with the regulation of stress and fear. However, few studies have focused on the role of thalamic CRF neurons in fear memory.

Nimotuzumab Combined With Irradiation Enhances the Inhibition to the HPV16 E6-Promoted Growth of Cervical Squamous Cell Carcinoma.

Human papillomavirus (HPV) 16 E6 has been proved to increase the radiosensitivity and lead to the EGFR overexpression in cervical cancer cells. In this study, to investigate the inhibition of nimotuzumab-mediated EGFR blockade combined with radiotherapy, we established a C33A cervical squamous cell line overexpressed HPV16-E6 and a nude mouse model bearing these cell lines. The CCK-8 assay was used to detect the effects of various treatments on the proliferation of C33A cells.

Syntheses of high molecular weight hydroxy functional copolymers by green and selective polycondensation methods.

Synthesizing hydroxy-functional linear copolymers with high molecular weights ( ) and low branching degree (Den%) remains challenging, although there has been much headway in the area of functional copolymers. Here, we studied the effect of polymerization methods (one-step or two-step) and solvents (organic solvent: diphenyl ether or ionic liquids: [C mim]TFN/BF/PF, = 2, 4, 6, 8, or 10) on and Den% of copolymers P(OA-GA) (1,8-octanediol adipate (O-A)/glycerol adipate (G-A)). The of P(OA-GA) reached up to 53 937 g mol in two-step in diphenyl ether, and the Den% of glycerol can be controlled within 30%.

Murine SIGNR1 (CD209b) Contributes to the Clearance of Uropathogenic During Urinary Tract Infections.

Uropathogenic (UPEC), a Gram-negative bacterial pathogen, is a major causative agent of urinary tract infections (UTIs). However, the molecular mechanisms of how UPEC causes infections have not been determined. Recent studies indicated that certain enteric Gram-negative bacteria interact with and hijack innate immune receptors DC-SIGN (CD209a) and SIGNR1 (CD209b), often expressed by antigen-presenting cells (APCs), such as macrophages, leading to dissemination and infection.

Flocculant-Assisted Synthesis of Graphene-Like Carbon Nanosheets for Oxygen Reduction Reaction and Supercapacitor.

The rational treatment of hazardous textile sludge is critical and challenging for the environment and a sustainable future. Here, a water-soluble chitosan derivative was synthesized and used as an effective flocculant in removal of reactive dye from aqueous solution. Employing these chitosan-containing textile sludges as precursors, graphene-like carbon nanosheets were synthesized through simple one-step carbonization with the use of Fe (III) salt as graphitization catalyst.

N, S Dual-Doped Carbon Derived from Dye Sludge by Using Polymeric Flocculant as Soft Template.

Dye sludge is a major by-product and it will bring critical environmental problems in the textile industry. In this study, dicyandiamide formaldehyde resin (DFR) is used as an effective flocculating agent for the removal of anionic dyes from textile dye wastewater. Employing dye-contaminated sewage sludges as precursors, N, S dual-doped carbon materials are successfully synthesized by using DFR as a soft template.

Cu-Doped Porous Carbon Derived from Heavy Metal-Contaminated Sewage Sludge for High-Performance Supercapacitor Electrode Materials.

In this paper, we report a complete solution for enhanced sludge treatment involving the removal of toxic metal (Cu(II)) from waste waters, subsequent pyrolytic conversion of these sludge to Cu-doped porous carbon, and their application in energy storage systems. The morphology, composition, and pore structure of the resultant Cu-doped porous carbon could be readily modulated by varying the flocculation capacity of Cu(II). The results demonstrated that it exhibited outstanding performance for supercapacitor electrode applications.