Prognostic significance of hemoglobin, albumin, lymphocyte and platelet score in solid tumors: a pooled study.

Objective: The high hemoglobin, albumin, lymphocyte, and platelet (HALP) score has been reported to be a good prognostic indicator for several malignancies. However, more evidence is needed before it can be introduced into clinical practice. Here, we systematically evaluated the predictive value of HALP for survival outcomes in patients with solid tumors.

Improving the Uniformity and Stretchability of Inkjet-Printed Films by Adding the Surfactant Triton X.

Stretchable organic light-emitting diodes (OLEDs) are a key component of stretchable electronics. Inkjet printing is a potential processing method for stretchable and flexible OLEDs. However, improving the uniformity and stretchability of the emission layer (EML) prepared by inkjet printing is challenging.

Research on cognitive neural mechanism of consumers convinced by intelligent recommendation platform eavesdropping.

The negative inference that consumers hold 'eavesdropping' views concerning the intelligent recommendation services of digital platforms is fostering their selective exposure to information that aligns with their preferred viewpoints. This, in turn, exacerbates their psychological defense against digital platforms, causing consumers to become more prone to verifying existing beliefs and fostering the polarization of information choices. This phenomenon directly impacts the effectiveness of smart recommendations and the accuracy of digital platforms' predictions of consumer behavior, potentially even adversely affecting brand trust and the long-term stability of platform usage.

Efficacy and Safety Analysis in Chinese Patients with Moderate-to-Severe Psoriasis from a Phase 3 Trial: Impact of Treatment Withdrawal and Retreatment of Ixekizumab.

Introduction: In China, approximately 2.3 million people have psoriasis. Continuous treatment is recommended for moderate-to-severe psoriasis.

Intentional or Designed? The Impact of Stance Attribution on Cognitive Processing of Generative AI Service Failures.

Background: With the rapid expansion of the generative AI market, conducting in-depth research on cognitive conflicts in human-computer interaction is crucial for optimizing user experience and improving the quality of interactions with AI systems. However, existing studies insufficiently explore the role of user cognitive conflicts and the explanation of stance attribution in the design of human-computer interactions.

Methods: This research, grounded in mental models theory and employing an improved version of the oddball paradigm, utilizes Event-Related Spectral Perturbations (ERSP) and functional connectivity analysis to reveal how task types and stance attribution explanations in generative AI influence users' unconscious cognitive processing mechanisms during service failures.

The influence of message frame and product type on green consumer purchase decisions : an ERPs study.

Green consumption is a crucial pathway towards achieving global sustainability goals. Product-oriented green advertisements can effectively stimulate consumers' latent needs and convert them into eventual purchasing intentions and behaviors, thereby promoting green consumption. Given that neuromarketing methods facilitate the understanding of consumers' decision-making processes, this study combines prospect theory and need fulfillment theory, employing event-related potentials (ERPs) as measures to explore changes in consumers' cognitive resources and emotional arousal levels when confronted with green products and advertising information.

Exploring the Relationship Between Education, Living Environment, and Anxiety/Depression Among Stable Patients: Insights from the COPD-AD China Registry Study.

Background: Education and living environment are related to mental health. But the independent and combined effects of them on mental health among patients with chronic obstructive pulmonary disease (COPD) are uncertain.

Methods: The independent and combined effects of education and living environment on mental health were assessed by binary logistic regression in 1064 COPD patients.

Notch-1 regulates collective breast cancer cell migration by controlling intercellular junction and cytoskeletal organization.

Pathological observations show that cancer cells frequently invade the surrounding normal tissue in collective rather than individual cell migration. However, general principles governing collective cell migration remain to be discovered. Different from individual cell migration, we demonstrated that the Notch-1-activation reduced collective cells speed and distances.

HECTD2 as a target for veratric acid in the regulation of ferroptosis in renal cell carcinoma.

Function of HECTD2 in renal cell carcinoma malignant progression is undefined. Molecular mechanism behind anti-cancer effects of veratric acid (VA) from traditional Chinese medicine (TCM) is underexplored. The Cancer Genome Atlas was leveraged to study HECTD2 expression in renal cell carcinoma and its relationship with histological grading.

High-performance cellulose/thermoplastic polyurethane composites enabled by interaction-modulated cellulose regeneration.

Strong interfacial adhesion between cellulose and other polymers is critical to achieve the properties required for specific applications in composite materials. Here, we developed a method for the simultaneous homogeneous dissolution of cellulose and thermoplastic polyurethane (TPU) in 1,8-diazabicyclo (5.4.

A prognostic model constructed by ferroptosis-associated genes (FAGs) in papillary renal cell carcinoma (PRCC) and its association with tumor mutation burden (TMB) and immune infiltration.

Background: This study aimed to identify the prognostic-related differentially expressed ferroptosis-associated genes (DEFAGs) in papillary renal cell carcinoma (PRCC).

Methods: Data encompassing simple nucleotide variation, transcriptome profiles, and relevant clinical information of PRCC patients were sourced from The Cancer Genome Atlas (TCGA) database. The expression matrix of ferroptosis-associated genes (FAGs) was analyzed using the "limma" package in R to identify differentially expressed DEFAGs.

Novel insights into the heterogeneity of FOXP3 + Treg cells in drug-induced allergic reactions through single-cell transcriptomics.

This study uncovers the novel heterogeneity of FOXP3 + regulatory T (Treg) cells and their pivotal role in modulating immune responses during drug-induced allergic reactions, employing cutting-edge single-cell transcriptomics. We established a mouse model for drug-induced allergic reactions and utilized single-cell RNA sequencing (scRNA-seq) to analyze the transcriptomic landscapes of FOXP3 + Treg cells isolated from affected tissues. The study involved both in vitro and in vivo approaches to evaluate the impact of FOXP3 expression levels on the immunoregulatory functions of Treg cells during allergic responses.

Di-(2-ethylhexyl) phthalate promotes benign prostatic hyperplasia through KIF11-Wnt/β-catenin signaling pathway.

Di-(2-ethylhexyl) phthalate (DEHP) might led to chronic and long-term effects on human organs due to its widespread use and bioaccumulation. Despite some cohorts reporting an association between DEHP exposure and BPH, its underlying mechanisms have not been investigated. Our findings indicate that exposure to DEHP or MEHP (main metabolites of DEHP in the human body) leads to increased prostate weights, elevated prostate index, and notable epithelial thickening in rats.

Knowledge, attitudes, and practices towards urinary system stones among the Chengdu population.

This cross-sectional study aimed to explore the knowledge, attitudes, and practices (KAP) regarding urinary system stones among the general public in Chengdu, China. Conducted between January and June 2023, this research targeted individuals undergoing physical examinations at the Health Management Center of Sichuan Provincial People's Hospital. Structured questionnaires were administered to collect demographic information and assess KAP related to urinary system stones.

Superstrong Ionogel Enabled by Coacervation-Induced Nanofibril Assembly for Sustainable Moisture Energy Harvesting.

Ionogels have grabbed significant interest in various applications, from sensors and actuators to wearable electronics and energy storage devices. However, current ionogels suffer from low strength and poor ionic conductivity, limiting their performance in practical applications. Here, inspired by the mechanical reinforcement of natural biomacromolecules through noncovalent aggregates, a strategy is proposed to construct nanofibril-based ionogels through complex coacervation-induced assembly.

HECTD2/TNFAIP1 Axis Regulating the p38/JNK Pathway to Promote an Inflammatory Response in Renal Cell Carcinoma Cells.

Background/aim: The underlying processes of renal cell carcinoma (RCC), one of the deadliest malignancies of the urinary system, are still poorly understood. HECT domain E3 ubiquitin protein ligase 2 (HECTD2) is an E3 ubiquitin ligase implicated in the pulmonary inflammatory response. This study investigated the impact of HECTD2 on regulating inflammation in RCC cells and its potential mechanisms.

Comparison of outcomes and characteristics of patients admitted to the ICU with COVID-19 and other community-acquired pneumonia based on propensity score matching.

Objective: To compare the similarities and differences between patients with Coronavirus Disease 2019 (COVID-19) and those with other community-acquired pneumonia (CAP) admitted to the intensive care unit (ICU), utilizing propensity score matching (PSM), regarding hospitalization expenses, treatment options, and prognostic outcomes, aiming to inform the diagnosis and treatment of COVID-19.

Methods: Patients admitted to the ICU of the Third People's Hospital of Datong City, diagnosed with COVID-19 from December 2022 to February 2023, constituted the observation group, while those with other CAP admitted from January to November 2022 formed the control group. Basic information, clinical data at admission, and time from symptom onset to admission were matched using PSM.

Research on the cognitive neural mechanism of privacy empowerment illusion cues regarding comprehensibility and interpretability for privacy disclosures.

In the era of artificial intelligence, privacy empowerment illusion has become a crucial means for digital enterprises and platforms to "manipulate" users and create an illusion of control. This topic has also become an urgent and pressing concern for current research. However, the existing studies are limited in terms of their perspectives and methodologies, making it challenging to fully explain why users express concerns about privacy empowerment illusion but repeatedly disclose their personal information.

Fast Energy Storage of SnS Anode Nanoconfined in Hollow Porous Carbon Nanofibers for Lithium-Ion Batteries.

The development of conversion-typed anodes with ultrafast charging and large energy storage is quite challenging due to the sluggish ions/electrons transfer kinetics in bulk materials and fracture of the active materials. Herein, the design of porous carbon nanofibers/SnS composite (SnS @N-HPCNFs) for high-rate energy storage, where the ultrathin SnS nanosheets are nanoconfined in N-doped carbon nanofibers with tunable void spaces, is reported. The highly interconnected carbon nanofibers in three-dimensional (3D) architecture provide a fast electron transfer pathway and alleviate the volume expansion of SnS , while their hierarchical porous structure facilitates rapid ion diffusion.

Tough soldering for stretchable electronics by small-molecule modulated interfacial assemblies.

The rapid-developing soft robots and wearable devices require flexible conductive materials to maintain electric functions over a large range of deformations. Considerable efforts are made to develop stretchable conductive materials; little attention is paid to the frequent failures of integrated circuits caused by the interface mismatch of soft substrates and rigid silicon-based microelectronics. Here, we present a stretchable solder with good weldability that can strongly bond with electronic components, benefiting from the hierarchical assemblies of liquid metal particles, small-molecule modulators, and non-covalently crosslinked polymer matrix.

Microphase-Separated Elastic and Ultrastretchable Ionogel for Reliable Ionic Skin with Multimodal Sensation.

Bioinspired artificial skins integrated with reliable human-machine interfaces and stretchable electronic systems have attracted considerable attention. However, the current design faces difficulties in simultaneously achieving satisfactory skin-like mechanical compliance and self-powered multimodal sensing. Here, this work reports a microphase-separated bicontinuous ionogel which possesses skin-like mechanical properties and mimics the multimodal sensing ability of biological skin by ion-driven stimuli-electricity conversion.

Study on roadway layout and surrounding rock control of isolated island panel.

During the re-mining of historical residual coal resources, the stress environment is complex, the surrounding rock conditions are bad, the mining roadway is significantly affected by ground pressure, the layout is difficult, and the safety is poor. Taking the recovery of isolated island coal pillar in 4# coal seam as the research background, based on the difference in the distribution morphology of the goaf on both sides of the isolated island coal pillar, the stress and failure law of the isolated island panel boundary are studied by numerical simulation method. (1) The peak stress difference of multiple goaf boundaries on both sides of the isolated island coal pillar is between 0.

A pan-cancer analysis reveals the diagnostic and prognostic role of CDCA2 in low-grade glioma.

Background: Cell division cycle associated 2 (CDCA2), a member of the cell division cycle associated proteins (CDCA) family, is crucial in the regulation of cell mitosis and DNA repair. CDCA2 was extensively examined in our work to determine its role in a wide range of cancers.

Methods: CDCA2 differential expression was studied in pan-cancer and in diverse molecular and immunological subgroups in this research.

The Influence of Tourist Attraction Type on Product Price Perception and Neural Mechanism in Tourism Consumption: An ERP Study.

Background: Tourism consumption is a topic with heated debates in tourism research, and pricing tourism products is a crucial task for tourism managers. Different types of tourist attractions offer different experiences to tourists, which affect their price perceptions and purchase decisions.

Methods: This study combined questionnaires and event-related potentials (ERPs) measures to explore the magnitude of psychological conflict and the degree of emotional arousal that consumers experience when faced with different prices of goods in different scenic types.