Measurable Residual Disease Assessed by Flow-Cytometry Is a Stable Prognostic Factor for Pediatric T-Cell Acute Lymphoblastic Leukemia in Consecutive SEHOP Protocols Whereas the Impact of Oncogenetics Depends on Treatment.

Robust and applicable risk-stratifying genetic factors at diagnosis in pediatric T-cell acute lymphoblastic leukemia (T-ALL) are still lacking, and most protocols rely on measurable residual disease (MRD) assessment. In our study, we aimed to analyze the impact of , and mutations, the measurable residual disease (MRD) levels assessed by flow cytometry (FCM-MRD) and other reported risk factors in a Spanish cohort of pediatric T-ALL patients. We included 199 patients treated with SEHOP and PETHEMA consecutive protocols from 1998 to 2019.

Repetitive syncopal episodes in a child with documented ventricular tachycardia, early repolarization pattern in leads I an aVL, Brugada syndrome, and fever.

We present a small child with febrile peaks and syncopal episodes secundary to ventricular tachycardia, in whom it was eventually possible to demostrate the Brugada Syndrome with a special presentation in the ECG; early repolarization pattern in lead I and a aVL and Brugada pattern during fever in V1-V2. This is, to our knowledge, tha first case with this special ECG presentation in a small child.

Motivation and E-Learning English as a foreign language: A qualitative study.

The motivation to learn a foreign language is a complex process. According to the Ministry of National Education of Colombia -MEN-, speaking English is a generic competence to be developed at all educational levels. In this regard and based on the Theory of Self-Determination -SDT-, this qualitative phenomenological study aims to identify and analyse the aspects related to the motivation to learn English in undergraduate students of the Virtual and Distance modalities -E-Learning-.

Heating and Soaking Influence in Vitro Hindgut Fermentation of Tropical Legume Grains in Pigs.

The effects of different thermal (raw versus autoclaving or boiling for 5 and 20 min) and soaking (with or without) treatments on the in vitro hindgut fermentation in pigs of undigested residue collected after in vitro foregut digestion of tropical legumes' grains (Canavalia brasiliensis; Lablab purpureus; pink, red and white Vigna unguiculata) were investigated. The undigested residue was fermented with a pig fecal inoculum to determine fermentability, gas, and short-chain fatty acid (SCFA) productions. Soaked raw legumes increased the production of SCFAs (e.

[Application of a social capital scale in older women attending public primary care clinics].

Background: Social capital is an economical idea that refers to connections between individuals and entities that can be economically valuable.

Aim: To establish the relationship of social capital as a health care asset, with sociodemographic variables of older women attending public health care services.

Material And Methods: Chen’s Personal Social Capital scale was applied to 113 women aged between 64 and 80 years during 2014.

The impact of heating and soaking on the in vitro enzymatic hydrolysis of protein varies in different species of tropical legumes.

The effects of different thermal (raw, autoclaving or boiling for 5 and 20min) and soaking (with or without) treatments on the degree of hydrolysis (DH) of protein were investigated for selected legumes (Canavalia brasiliensis; Lablab purpureus; pink, red and white colour hulls Vigna unguiculata). Each legume preparation underwent in vitro simulated gastrointestinal tract digestion comprising either pepsin (120min) or pepsin/pancreatin (120/240min) digestion. The DH was determined based on the amount of free amino groups released.

Dual Antiplatelet Therapy for 6 Months vs 12 Months After New-generation Drug-eluting Stent Implantation: Matched Analysis of ESTROFA-DAPT and ESTROFA-2.

Introduction And Objectives: The recommendation for dual antiplatelet therapy following drug-eluting stent implantation ranges from 6 months to 12 months or beyond. Recent trials have suggested the safety of a 6-month dual antiplatelet therapy regimen, yet certain caveats to these studies limit the applicability of this shorter duration dual antiplatelet therapy strategy in real world settings.

Methods: A registry was constructed with consecutive recruitment of patients undergoing new-generation drug-eluting stent implantation and prescribed 6 months of dual antiplatelet therapy.

Social protection systems in vulnerable families: their importance for the public health.

OBJECTIVE To analyze the effectiveness of the Chilean System of Childhood Welfare in transferring benefits to socially vulnerable families. METHODS A cross-sectional study with a sample of 132 families from the Metropolitan Region, Chile, stratified according to degree of social vulnerability, between September 2011 and January 2012. Semi-structured interviews were conducted with mothers of the studied families in public health facilities or their households.

Effectiveness of the Comprehensive Childhood Protection System for vulnerable mothers and children.

Objectives: To establish the effectiveness of the public benefits and services of the "Chile Grows with You" and "Protect Network" programs for socially vulnerable women and children in an urban community in the Metropolitan Region of Chile.

Method: Descriptive study employing a questionnaire. The sample consisted of 132 mothers and their 133 infants, all grouped according to social vulnerability.

The motherhood experience in the context of social vulnerability: a comprehensive approach to social phenomenology.

Objective: to understand the future expectations and experience of vulnerable mothers from pregnancy to their child's early years.

Methods: this qualitative study used the social phenomenology of Alfred Schütz as a framework. From January to April 2011, nine mothers from the 2009 program "Chile Grows with You" were interviewed at health centers in an urban Santiago de Chile community.

Nurses and care delivery to elderly women: a social phenomenological approach.

Objective: To understand how nurses see care delivery to elderly women.

Methods: In this phenomenological study, ten nurses working at Primary Health Care Units were interviewed between September 2010 and January 2011.

Results: In care delivery, nurses consider the elderly women's knowledge background and biographical situation, and also value the family's participation as a care mediator.

[Vulnerability of pregnant women living in a community of Metropolitan Santiago].

Background: The program "Chile grows with you" is a part of the Chilean social protection system oriented to decrease social inequities from pregnancy (a socially secure pregnancy) to four years of age, directed to the poorest 40% of the population.

Aim: To determine the incidence of social vulnerability and its determinants, starting at the gestation period.

Material And Methods: Data was obtained from anonymous secondary data based on the records of the first assessment of pregnant women and from social protection surveys, provided by the Ministry of Planning and Cooperation.

Nursing teachers in clinical training areas: a phenomenological focus.

During theoretical and practical activities in clinical training areas, nursing teachers provide the bases needed for the development of future professionals. The goal is to understand the experience of nursing teachers with nursing students in clinical training areas. Therefore, a phenomenological qualitative method was chosen, and Martin Heidegger's philosophical framework was used to support data analysis.

Cavotricuspid isthmus catheter ablation without the use of fluoroscopy as a first-line treatment.

Introduction And Objectives: The use of intracardiac navigation systems has enabled a significant reduction of the radiation dose in the majority of ablation procedures. The purpose of this study is to evaluate the feasibility and safety of cavotricuspid isthmus ablation without the use of fluoroscopy as a first-line treatment.

Methods And Results: An observational study without a control group in patients referred for treatment of common atrial flutter.

Correlation between immature platelet fraction and reticulated platelets. Usefulness in the etiology diagnosis of thrombocytopenia.

Background: Reticulated platelets (RP) are a surrogate marker for megakaryocytic activity, but the limitation of this determination is the lack of standardization of methodology. The determination of the immature platelet fraction (IPF) is performed in a simple, automated, and reproducible way between laboratories. We analyzed the correlation between IPF and RP, and usefulness of IPF in patients with thrombocytopenia.

Low reticulocyte hemoglobin content is associated with a higher blood transfusion rate in critically ill patients: a cohort study.

Background: Intensive care unit (ICU) patients often need blood transfusion, but no reliable predictors of transfusion requirements are available at ICU admission. The authors hypothesized that ICU patients with functional iron deficiency may be at higher risk for developing anemia, requiring blood transfusion. Their objective was to determine whether low reticulocyte hemoglobin content (CHr) was associated with transfusion requirements in ICU patients.

[The experience of clinical nurses with nursing students: a phenomenological analysis].

This study aimed at understanding the reality of being a clinical nurse who works with nursing students while they develop their care experience in the clinical practice. The research was carried out by means of a phenomenological approach. Nine clinical nurses were interviewed and based on their discourses four categories of concretely experienced events were identified and interpreted according to Martin Heidegger's philosophical reference.

[Relationship between reticulated platelets and megacaryocyte number in thrombocytopenic patients].

Background And Introduction: Marrow aspiration is a test that helps the pathogenic diagnosis of thrombocytopenia. Our goal was to analyze the correlation between reticulated platelets (RP) values in peripheral blood with megakaryocytic number in bone marrow in a group of thrombocytopenic patients.

Patients And Methods: Prospective observational study in thrombocytopenic patients, between June 2002 and June 2005.

Comparative analysis of ZAP-70 expression and Ig VH mutational status in B-cell chronic lymphocytic leukemia.

Background: B-cell chronic lymphocytic leukemia (CLL) is a heterogeneous disorder with respect to its clinical course. Accurate identification of prognostic factors is becoming increasingly important in order to determine those patients requiring aggressive treatments. Two of the most predictive outcome markers are the Ig VH mutational gene status and ZAP-70 expression.

Ephrin-A5 inhibits growth of embryonic sensory neurons.

EphA-ephrin signaling has recently been implicated in the establishment of motor innervation patterns, in particular in determining whether motor axons project into dorsal versus ventral nerve trunks in the limb. We investigated whether sensory axons, which grow out together with and can be guided by motor axons, are also influenced by Eph-ephrin signaling. We show that multiple EphA receptors are expressed in DRGs when limb innervation is being established, and EphA receptors are present on growth cones of both NGF-dependent (predominantly cutaneous) and NT3-dependent (predominantly proprioceptive) afferents.

[Symbolic meanings of patients with chronic diseases].

The investigation presents three cultural universes of those suffering from arterial hypertension, diabetes and arthrosis, describing the different dimensions and interpreting their meaning. The ethnographic method was utilized, using the ethnographic interview and participant observation and for the interpretation, the symbolic interactionism and other authors. Convergences in the dimensions arise in which the three diseases are perceived: the loss of well-being and social support, fear of disability and death.

The simian virus 40 minor structural protein Vp3, but not Vp2, is essential for infectious virion formation.

The SV40 capsid is composed of pentameric capsomeres of the major structural protein Vp1. The two minor structural proteins, Vp2 and Vp3, interact with the capsid. Here, the roles of Vp2 and Vp3 were explored during the course of SV40 infection.

Immunophenotypic findings in acute myeloid leukemia with FLT3 internal tandem duplication.

Background And Objectives: The biological characteristics and the prognostic significance of the internal tandem duplication of the FLT3 (FLT3/ITD) were investigated in a series of de novo acute myeloid leukemia (AML) patients. One hundred and fifty-six adult patients with AML were included in the study. FLT3/ITD was detected in 41 (26%) patients (FLT3/ITD(+)).