Association of free fatty acids with the insulin-resistant state but not with central obesity in individuals from Venezuela.

Individuals with insulin resistance (IR) usually have upper body obesity phenotype, often accompanied by an increase in plasma free fatty acids (FFA). Since the Venezuelan population has a high frequency of IR and central obesity, the purpose of this work was to determine FFA levels in 47 Venezuelan individuals, men and women, 24-58 years old, and analyze their relationship with central obesity and parameters of carbohydrate and lipid metabolism. Basal concentrations of TG, total cholesterol, LDL-C, and HDL-C were measured, and FFA, glucose and insulin, at basal state and at different times after a glucose load.

[Gly482Ser polymorphism of the coactivator-1alpha of the activated receptor of peroxisome gamma proliferation in individuals from Maracaibo, Venezuela].

The aim of this study was to determine the association of the Gly482Ser polymorphism of the PGC-1 gene with insulin resistance and type 2 diabetes mellitus in subjects from the city of Maracaibo. The study was performed on 64 no-diabetic subjects (36 without insulin resistance and 28 with insulin resistance) and 13 with type 2 diabetes. A clinical and nutritional history was carried out and the evaluation of anthropometric parameters was included.

[Distribution of fasting glucose, insulin, homeostasis model assessment (HOMA) insulin resistance (IR) and HOMA beta cell in children and adolescents from Maracaibo, Venezuela].

Background: The raising prevalence of obesity among children increases the risk of insulin resistance and its adverse metabolic consequences.

Aim: To determine the distributions of fasting serum glucose, insulin, HOMA IR and HOMA beta cell in a representative sample of children and adolescents from Maracaibo-Venezuela.

Subjects And Methods: Fasting insulin and glucose were measured in 418 children and adolescents (191 boys and 227 girls) of 7, 9, 11, 13, 15 years of age.

[Basal insulin levels in a Zulia State population in Venezuela].

This study examines the basal insulin levels in a population from Zulia state (Venezuela). A total of 1703 subjects (1175 women and 528 men) from five different sanitary regions (Maracaibo, La Guajira, Perijá, Sur del Lago de Maracaibo, y Costa Oriental del Lago de Maracaibo) were studied. Weight, height, waist and hip circumferences, and blood pressure were determined.

[Serum insulin, leptin and growth hormone levels are associated with body mass index and obesity index in adolescents].

Leptin, insulin and growth hormone levels seem to regulate body composition, fat distribution and fat mass. The purpose of this study was to determine the relationship among insulin, leptin and growth hormone levels in a group of adolescents. Ninety five adolescents (31 boys and 64 girls) between 13 and 18 y.

[Levels of apoproteins B, A1 and CIII as markers for cardiovascular risk in lean and obese adolescents].

Cardiovascular disease is a significant health problem affecting the adult population. Because atherosclerosis may begin in childhood, the aim of the present study was to identify biochemical markers for cardiovascular risk at an early stage of life. We studied 79 adolescents (48 girls and 31 boys) whose ages ranged from 13 to 17 years.

Lean adolescents with increased risk for metabolic syndrome.

The aim of the present study was to determine in adolescents the relationship between insulin levels and body mass index (BMI), body fat distribution, diet, life style and lipid profile. We studied 167 adolescents (68 boys and 99 girls) whose ages ranged from 14 to 17 years. A detailed medical (including pubertal stage) and nutritional record was obtained from each subject.